eroy@illinois.edu
336A Burrill Hall
Office: (217) 333-3375
Lab: (217) 244-2823
Mail to:
Department of Pathology
College of Medicine, UIUC
506 S. Mathews Ave
Urbana, IL 61801
Ed Roy
Professor of Molecular and Integrative Physiology, Pathology, and Neuroscience
Education
B.A. 1970 Brown University
Ph.D. 1976 University of Massachusetts
Postdoc. 1976-1979 The Rockefeller University
Teaching Interests
Immunotherapy
We are committed to developing immunotherapies for brain tumors that are effective and selective. We use mice as experimental subjects because much is know about their immune system, and the murine system closely parallels the human immune system. When properly activated, the immune system has the characteristics of an ideal therapy: potent, precise killing of altered cells. But there is much to be learned about how to activate, direct, and control the immune response, particularly against tumors within the brain. We focus mostly on T cell mediated immune responses, and work in close collaboration with the laboratory of David Kranz, a T cell biochemist.
Representative Publications
Fan, T.M., Kranz, D.M., and Roy, E.J. 2006. Enhancing antitumor immunity: combining IL-12 with TGFß1 antagonism. J. Immunotherapy, In Press.
Roy, E.J., Takikawa, O., Kranz, D.M., Brown, A.R., and Thomas, D.L. 2005. Neuronal localization of indoleamine 2,3-dioxygenase in mice. Neuroscience Letters, 387(2):95–9. [Abstract]
Gawlick, U., Kranz, D.M., Schepkin, V.D., and Roy, E.J. 2004. A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors. Bioconjugate Chemistry, 15(5):1137–45. [Abstract]
Roy, E.J., Gawlick, U. Orr, B.A., and Kranz, D.M.. 2004. Folate-mediated targeting of T Cells to tumors. Advanced Drug Delivery Reviews, 56(8):1219–31. [Abstract]
Roy, E.J., Kim, M., Soto, C.M., and Thomas, D.L. August 2006. Does stroma play a role in T cell mediated rejection of brain tumors? Aspen Symposium on Brain Tumor Immunotherapy
Odintsov, B., Atasarkin, V., Gorbenko, O., Kaul, A., and Roy, E.J. Adjustable Curie-temperature nanoparticles for imaging and highly controllable hyperthermia cancer therapy. International Conference on Composites or Nano Engineering, July 2006.
Thomas, D.L., Brown, A.R., and Roy, E.J. Immunostimulatory CpG DNA increases brain tumor infiltrating T cells. Society for Neuroscience, November 2005.