katzenel@life.illinois.edu
294 Burrill Hall
Office: (217) 333-9769
Lab: (217) 333-7838/3-7836
Fax: (217) 244-9906
Mail to: Department of Molecular and Integrative Physiology
524 Burrill Hall
407 S. Goodwin Ave
Urbana, IL 61801
Benita S Katzenellenbogen
Swanlund Professor of Molecular and Integrative Physiology
Swanlund Professor of Cell and Developmental Biology
Research Topics
Endocrinology, Genomics, Protein-Nucleic Acid Interactions, Receptor Biochemistry, Regulation of Gene Expression, Reproductive Biology, Signal Transduction
Education
B.A. 1965 City University of New York
M.A. 1966 Harvard University
PhD. 1970 Harvard University
Postdoc. 1970-71 University of Illinois
Regulation of gene expression, signal transduction, and cell proliferation by hormones and growth factors; mechanisms of hormone and antihormone action in normal and cancer cells; functional analyses of nuclear hormone receptors and their genome-wide activities
We are interested in understanding the biochemistry, physiology, and molecular biology of nuclear hormone (estrogen, progesterone) receptors, intracellular proteins that mediate the biological actions of these hormones in target cells, and the mechanisms by which these proteins regulate gene expression and the growth and functioning of target cells, especially cells of the reproductive system and mammary gland, and of tumors that develop in these tissues. Our studies focus on the characterization of these receptors and their coregulator protein partners; the interaction of receptor agonist versus antagonist ligand complexes with hormone-regulated genes; the interrelationships among hormones, growth factors, and various signal transduction pathways in the regulation of cell proliferation; and the mechanisms by which antihormones (antiestrogens and antiprogestins) antagonize hormone-dependent gene transcription and cell growth. We are doing genome-wide analyses of receptor cistromes (chromatin binding sites) and transcriptomes (gene expression) and are examining the bidirectional cross-talk between nuclear hormone receptors and cell signal transduction pathways. Our studies involve detailed biochemical and structure-function analyses of the receptors and their gene interactions, and examination of their biological activities in normal and cancer, in particular breast cancer, cells. We have a major interest in hormones and breast cancer and in mechanisms of endocrine sensitivity and resistance in cancer; and also a strong focus on reproductive biology and the improvement of fertility.
Awards
Ernst Oppenheimer Memorial Award of The Endocrine Society for Meritorious Research, 1984
Thomas A. Murphy University Scholar, 1987-1990
MERIT Award from National Institutes of Health, National Cancer Institute 1991-1999
Faculty Member of the Year Award, University of Illinois College of Medicine, 1994
American Academy of Arts and Sciences, elected Fellow, 1993
Susan G. Komen Breast Cancer Foundation, Scientific Distinction Award, 1996
The Kroc Lectureship, Univ. Texas-Houston Health Science Center and M. D. Anderson Cancer Center, 1998
Jill Rose Award for Breast Cancer Research,
The Breast Cancer Research Foundation, 1998
NIEHS Distinguished Lectureship, NIEHS/NIH, 2000 and 2005
Swanlund Professorship, University of Illinois, 2000-present
Professor in the Center for Advanced Studies, University of Illinois, 2000-present
City University of New York Distinguished Alumni Award, 2002
Roy O. Greep Lecture Award, The Endocrine Society, 2006
Laurea ad Honorem (Honorary Degree) from University of Milan, Italy, 2007
Nobel Conference on Estrogen Signaling: From Molecular Insights to Clinical Understanding, Keynote Address, Stockholm, 2008
Susan G. Komen for the Cure, Brinker Award for Scientific Distinction, 2009
Mentor Award, Women in Endocrinology, 2011
Representative Publications
Stossi, F., Madak-Erdogan, Z., and Katzenellenbogen, B.S. Macrophage-Elicited Loss of Estrogen Receptor-α in Breast Cancer Cells via Involvement of MAPK and c-Jun at the ESR1 Genomic Locus. Oncogene. 2011 Aug 23. doi:10.1038/onc.2011.370. [Abstract]
Park, S., Zhao, Y., Yoon, S., Xu, J., Liao, L., Lydon, J., DeMayo, F., O’Malley, B.W. and Katzenellenbogen, B.S. Repressor of Estrogen Receptor Activity (REA) is Essential for Mammary Gland Morphogenesis and Functional Activities: Studies in Conditional Knockout Mice. Endocrinology. 2011. doi:10.1210/en.2011-1100. [Abstract]
Stender, J.D., Stossi, F., Funk, C.C., Charn, T.H., Barnett, D.H., Katzenellenbogen, B.S. The Estrogen Regulated Transcription Factor PITX1 Coordinates Gene-Specific Regulation by Estrogen Receptor-Alpha in Breast Cancer Cells. Mol Endocrinol. 2011. doi:10.1210/me.2011-0102. [Abstract]
Bergamaschi, A., Christensen, B., Katzenellenbogen, B.S. Reversal of Endocrine Resistance in Breast Cancer: Interrelationships Among 14-3-3ζ, FOXM1, and a Gene Signature Associated with Mitosis. Breast Cancer Research. 2011. 13:R70, doi:10.1186/bcr2913. [Abstract]
Bergamaschi, A. and Katzenellenbogen, B.S. Tamoxifen down-regulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance. 2011. Oncogene. advance online publication 13 June 2011; doi: 10.1038/onc.2011.223. [Abstract]
Madak-Erdogan,Z., Lupien, M., Stossi, F., Brown, M., Katzenellenbogen, B.S. Genomic Genomic Collaboration of Estrogen Receptor and Extracellular Signal-Regulated Kinase 2 in Regulating Gene and Proliferation Programs. Mol. Cell. Biol. January 2011 31: 226-236. [Abstract]
Stender, J.D., Kim, K., Charn, T.H., Komm B., Chang K.C.N., Kraus, W.L., Benner, C., Glass C. K., Katzenellenbogen, B.S. Genome-Wide Analysis of Estrogen Receptor-α DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation. Mol. Cell Biol. 30:3943-3955, 2010. [Abstract]
Charn, T.H., Liu,E.T., Chang, E.C., Lee, Y.K., Katzenellenbogen, J.A., Katzenellenbogen, B.S. Genome-wide dynamics of chromatin binding of estrogen receptors α and β: Mutual restriction and competitive site selection. Mol. Endocrinol 24(1):47-59, 2010. [Abstract]
Stossi, F., Madak-Erdogan, Z., Katzenellenbogen, B. S. Estrogen receptor alpha represses transcription of early target genes via p300 and CtBP1. Mol. Cell Biol, 29:1749-59. 2009. [Abstract]
Madak-Erdogan, Z., Kieser, K. J., Kim, S. H., Komm, B., Katzenellenbogen, J. A., Katzenellenbogen, B. S. Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors. Mol. Endocrinol., 22:2116-2127, 2008. [Abstract]
Barnett, D. H., Sheng, S., Charn, T. H., Waheed, A., Sly, W. S., Lin, C. Y., Liu, E. T., Katzenellenbogen, B. S. Estrogen receptor regulation of Carbonic Anhydrase XII through a distal enhancer in breast cancer. Cancer Research, 68:3505-15, 2008. [Abstract]
Chang, E.C., Charn, T. H., Park, S. H., Helferich, W. G., Komm, B., Katzenellenbogen, J. A., Katzenellenbogen, B. S. Estrogen receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding. Mol. Endocrinol., 22:1032-43, 2008. [Abstract]