katzenel@life.illinois.edu
294 Burrill Hall
Office: (217) 333-9769
Lab: (217) 333-7838/3-7836
Fax: (217) 244-9906
Mail to:
Department of Molecular and Integrative Physiology
524 Burrill Hall
407 S. Goodwin Ave
Urbana, IL 61801
Benita S Katzenellenbogen
Swanlund Professor of Molecular and Integrative Physiology
Swanlund Professor of Cell and Developmental Biology
Education
B.A. 1965 City University of New York
M.A. 1966 Harvard University
PhD. 1970 Harvard University
Postdoc. 1970-71 University of Illinois
Regulation of gene expression, signal transduction, and cell proliferation by hormones and growth factors; mechanisms of hormone and antihormone action in normal and cancer cells; functional analyses of nuclear hormone receptors
We are interested in understanding the biochemistry, physiology, and molecular biology of nuclear hormone (estrogen, progesterone) receptors, intracellular proteins that mediate the biological actions of these hormones in target cells, and the mechanisms by which these proteins regulate gene expression and the growth and functioning of target cells, especially cells of the reproductive system and mammary gland, and of tumors that develop in these tissues. Our studies focus on the characterization of these receptors and their coregulator protein partners; the interaction of receptor agonist versus antagonist ligand complexes with hormone-regulated genes; the interrelationships among hormones, growth factors, and various signal transduction pathways in the regulation of cell proliferation; and the mechanisms by which antihormones (antiestrogens and antiprogestins) antagonize hormone-dependent gene transcription and cell growth. We are doing extensive microarray analyses in the profiling of gene expression, and are examining the bidirectional cross-talk between nuclear hormone receptors and cell signal transduction pathways. Our studies involve detailed biochemical and structure-function analyses of the receptors and their gene interactions, and examination of their biological activities in normal and cancer cells.
Representative Publications
Stossi, F., Madak-Erdogan, Z., Katzenellenbogen, B.S. Estrogen Receptor Alpha Represses Transcription of Early Target Genes via p300 and CtBP1. Mol. Cell. Biol. published 2 February 2009, 10.1128/MCB.01476-08
Stender, J. D., Frasor, J., Komm, B., Chang, K. C. N., Kraus, W. L., Katzenellenbogen, B. S. Estrogen regulated gene networks in human breast cancer cells: involvement of E2F1 in the regulation of cell proliferation, Mol. Endocrinol. 21: 2112 - 2123, 2007. [Abstract]
Chang, E. C., Frasor, J., Komm, B. and Katzenellenbogen, B. S. Impact of estrogen receptor beta on gene networks regulated by estrogen receptor alpha in breast cancer cells. Endocrinology, 147:4831-4842, 2006. [Abstract]
Frasor, J., Chang, E. C., Komm, B., Lin, C. Y., Vega, V. B., Liu, E. T., Miller, L. D., Smeds, J., Bergh, J. and Katzenellenbogen, B. S. Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Research, 66:7334-7340, 2006. [Abstract]
Harrington, W. R., Kim, S. H., Funk, C. C., Madak-Erdogan, Z., Schiff, R., Katzenellenbogen, J. A. and Katzenellenbogen, B. S. Estrogen dendrimer conjugates that preferentially activate extranuclear, non-genomic versus genomic pathways of estrogen action. Mol. Endocrinol., 20: 491-502, 2006. [Abstract]
Park, S.E., Xu, J., Frolova, A., Liao, L., O'Malley, B.W. and Katzenellenbogen, B.S. Genetic deletion of the repressor of estrogen receptor activity (REA) enhances response to estrogen in target tissues in vivo. Molec. Cell. Biol., 25: 1989-1999, 2005. [Abstract]
Frasor, J., Danes, J. M., Funk, C. C. and Katzenellenbogen B.S. Estrogen down-regulation of the corepressor N-CoR: Mechanism and implications for estrogen derepression of N-CoR-regulated genes. Proc. Natl. Acad. Sci. USA, 102:13153-13157, 2005. [Abstract]