Benita S Katzenellenbogen

katzenel@life.illinois.edu

294 Burrill Hall
Office: (217) 333-9769
Fax: (217) 244-9906

Mail to: Department of Molecular and Integrative Physiology
524 Burrill Hall
407 S. Goodwin Ave
Urbana, IL 61801-3704

Benita S Katzenellenbogen

Swanlund Professor of Molecular and Integrative Physiology
Swanlund Professor of Cell and Developmental Biology

Research Topics

Endocrinology, Genomics, Protein-Nucleic Acid Interactions, Receptor Biochemistry, Regulation of Gene Expression, Reproductive Biology, Signal Transduction

Education

B.A. 1965 City University of New York
M.A. 1966 Harvard University
PhD. 1970 Harvard University
Postdoc. 1970-71 University of Illinois

Regulation of gene expression, signal transduction, and cell proliferation and phenotypic properties by hormones and growth factors; functional analyses of nuclear hormone receptors and their genome-wide activities; mechanisms of hormone and antihormone action in normal and cancer cells; biomarker discovery and cellular changes underlying resistance to therapeutic agents in breast cancer.

We are interested in understanding the biochemistry, physiology, and molecular biology of nuclear hormone (estrogen, progesterone) receptors, intracellular proteins that mediate the biological actions of these hormones in target cells, and the mechanisms by which these proteins regulate gene expression and the growth and functioning of target cells, especially cells of the reproductive system and mammary gland, and of tumors that develop in these tissues. Our studies focus on the characterization of these receptors and their coregulator protein partners; the interaction of receptor agonist versus antagonist ligand complexes with hormone-regulated genes; the interrelationships among hormones, growth factors, and various signal transduction pathways in the regulation of cell proliferation and phenotypic properties of breast cancer cells; and the mechanisms by which antihormones (antiestrogens and antiprogestins) antagonize hormone-dependent gene transcription and cell growth. We are doing genome-wide analyses of receptor and other transcription factor cistromes (chromatin binding sites by ChIP-Seq) and transcriptomes (gene expression, miRNAs, other RNAs by RNA-Seq) and are examining the bidirectional cross-talk between nuclear hormone receptors and cell signaling pathways. Our studies involve detailed biochemical and structure-function analyses of the receptors and coregulators and their gene interactions, and examination of their biological activities in normal and cancer, in particular breast cancer, cells. We have a major interest in hormones and breast cancer and in mechanisms of endocrine sensitivity and resistance to cancer therapies; biomarker discovery and improving cancer treatment effectiveness; and also a strong focus on reproductive biology and the improvement of fertility.

Awards

Ernst Oppenheimer Memorial Award of The Endocrine Society for Meritorious Research, 1984
Thomas A. Murphy University Scholar, 1987-1990
MERIT Award from National Institutes of Health, National Cancer Institute 1991-1999
Faculty Member of the Year Award, University of Illinois College of Medicine, 1994
American Academy of Arts and Sciences, elected Fellow, 1993
Susan G. Komen Breast Cancer Foundation, Scientific Distinction Award, 1996
The Kroc Lectureship, Univ. Texas-Houston Health Science Center and M. D. Anderson Cancer Center, 1998
Jill Rose Award for Breast Cancer Research, The Breast Cancer Research Foundation, 1998
NIEHS Distinguished Lectureship, NIEHS/NIH, 2000 and 2005
President, The Endocrine Society, 2000-2001
Swanlund Professorship, University of Illinois, 2000-present
Professor in the Center for Advanced Studies, University of Illinois, 2000-present
City University of New York Distinguished Alumni Award, 2002
Roy O. Greep Lecture Award, The Endocrine Society, 2006
Laurea ad Honorem (Honorary Degree) from University of Milan, Italy, 2007
Nobel Conference on Estrogen Signaling: From Molecular Insights to Clinical Understanding, Keynote Address, Stockholm, 2008
Susan G. Komen for the Cure, Brinker Award for Scientific Distinction, 2009
Mentor Award, Women in Endocrinology, 2011
Plenary Lecturer, The Endocrine Society of Australia, Melbourne, August 2014
Fred Conrad Koch Lifetime Achievement Award, The Endocrine Society, 2016

Representative Publications

Madak-Erdogan Z, Kim SH, Gong P, Zhao YC, Zhang H, Chambliss KL, Carlson KE, Mayne CG, Shaul PW, Korach KS, Katzenellenbogen JA, Katzenellenbogen BS. Design of Pathway Preferential Estrogens Affording Beneficial Metabolic and Vascular Actions without Reproductive Tissue Stimulation. Science Signaling 9(429): ra53 2016. PMID:27221711. [Abstract]

Fanning SW, Mayne CG, Dharmarajan V, Carlson KE, Martin TA, Novick SJ, Toy W, Greene B, Panchamukhi S, Katzenellenbogen BS, Tajkhorshid E, Griffin PR, Shen Y, Chandarlapaty S, Katzenellenbogen JA, Greene GL. Estrogen Receptor Alpha Somatic Mutations Y537S and D538G Confer Breast Cancer Endocrine Resistance by Stabilizing the Activating Function-2 Binding Conformation. Elife 2016; Feb 2;5. pii: e12792. doi: 10.7554/eLife.12792 PMID:26836308. [Abstract]

Bhatt S, Stender JD, Joshi S, Wu G and Katzenellenbogen BS. OCT-4: A Novel Estrogen Receptor-α Collaborator That Promotes Tamoxifen Resistance in Breast Cancer Cells. Oncogene 2016, Apr 11. doi: 10.1038/onc.2016.105. [Epub ahead of print]. PMID: 27065334. [Abstract]

Zhao Y, Chen Y, Bagchi MK, Taylor RN, Katzenellenbogen JA, Katzenellenbogen BS. Multiple Beneficial Roles of Repressor of Estrogen Receptor Activity (REA) in Suppressing the Progression of Endometriosis. Endocrinology 157(2):900-12, 2016. Feb. doi: 10.1210/en.2015-1324. Epub 2015 Dec 14. PMID: 26653759. [Abstract]

Boonmuen N, Gong P, Ali Z, Chittiboyina AG, Khan I, Doerge DR, Helferich WG, Carlson KE, Martin T, Piyachaturawat P, Katzenellenbogen JA, and Katzenellenbogen BS. Licorice Root Components in Dietary Supplements are Selective Estrogen Receptor Modulators with a Spectrum of Estrogenic and Anti-Estrogenic Activities. Steroids 105:42-9, 2016 Jan. doi: 10.1002/mnfr.201500445. PMID: 26631549. [Abstract]

Zhao, Y., Gong, P., Chen, Y., Nwachukwu, J.C., Srinivasan, S., Ko, C.M., Bagchi, M.K., Taylor, R.N., Korach, K.S., Nettles, K.W., Katzenellenbogen, J.A., and Katzenellenbogen, B.S. Dual Suppression of Estrogenic and Inflammatory Activities for Targeting of Endometriosis. Sci Transl Med. 7(271):271ra9, 2015.PMID: 25609169. [Abstract]

Gong, P., Madak-Erdoğan, Z., Li, J., Cheng, J., Greenlief, C.M., Helferich, W.G., Katzenellenbogen, J.A., and Katzenellenbogen, B.S. Transcriptomic Analysis identifies gene networks regulated by ERα and ERβ that control distinct effects of different botanical estrogens. Nuclear Receptor Signaling. 2014, 12:e001. doi:10.162/nrs.12001. PMID: 25363786 PMCID: PMC4193135. [Abstract]

Bergamaschi, A., Madak-Erdoğan, Z., Kim, Y.J., Choi, Y.L., Lu, H. and Katzenellenbogen, B.S. The Forkhead Transcription Factor FOXM1 Promotes Endocrine Resistance and Invasiveness in Estrogen Receptor-Positive Breast Cancer by Expansion of Stem-like Cancer Cells. Breast Cancer Research. 16:436, 2014. PMID: 25213081. [Abstract]

Madak-Erdogan, Z., Ventrella, R., Petry, L., and Katzenellenbogen B.S. Novel roles for ERK5 and Cofilin as Critical Mediators Linking Estrogen Receptor α-Driven Transcription, Actin Reorganization and Invasiveness in Breast Cancer. Mol Cancer Res. 12:714-727, 2014. PMID: 24505128. [Abstract]

Holton, S.E., Bergamaschi, A., Katzenellenbogen, B.S. and Bhargava, R. Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer. PLoS One. 9(5):e96878, 2014. PMID: 24816718. [Abstract]

Madak-Erdogan, Z. Charn, T.H., Jiang, Y., Liu, S.T., Katzenellenbogen, J.A. and Katzenellenbogen B.S. Integrative Genomics of Gene and Metabolic Regulation by Estrogen Receptors α and β, and Their Coregulators. Molecular Systems Biology 9:676, 2013. PMID: 23774759 [Abstract]

Kim, K., Madak-Erdogan, Z. and Katzenellenbogen, B.S. A MicroRNA196a2* and TP63 Circuit Regulated by Estrogen Receptor- and ERK2 that Controls Breast Cancer Proliferation and Invasiveness Properties. Hormones and Cancer 4:78-91, 2013. PMID: 23250869. [Abstract]

Zhao, Y., Park, S., Bagchi, M.K., Taylor, R.N., and Katzenellenbogen, B.S. The Coregulator, Repressor of Estrogen Receptor Activity (REA), is Crucial in the Control of the Timing and Magnitude of Uterine Decidualization. Endocrinology 154:1349-1360, 2013. PMID: 23392257. [Abstract]

Bergamaschi, A., Frasor, J., Borgen, K., Stanculescu, A., Johnson, P., Rowland, K., Wiley, E.L., and Katzenellenbogen, B.S. 14-3-3 zeta as a Predictor of Early Time to Recurrence and Distant Metastasis in Hormone Receptor Positive and -Negative Breast Cancers. Breast Cancer Research and Treatment 137:689-696, 2013. PMID: 23271328. [Abstract]

Jiang, Y., Gong, P., Madak-Erdogan, Z., Martin, T., Jeyakumar, M., Carlson, K., Khan, I., Smillie, T.J., Chittiboyina, A.G., Rotte, S.C.K., Helferich, W.G., Katzenellenbogen, J.A. and Katzenellenbogen, B.S. Mechanisms Enforcing the Estrogen Receptor Beta-Selectivity of Botanical Estrogens. FASEB J 2013. PMID: 23882126. [Abstract]

Complete Publications List