M Joan Dawson

mjd@life.illinois.edu

488 Burrill Hall
Office: (217) 244-1295
Lab: (217) 244-4234
Fax: (217) 333-1133

Mail to: Department of Molecular and Integrative Physiology
524 Burrill Hall
407 S. Goodwin Ave
Urbana, IL 61801

M Joan Dawson

Associate Professor Emerita of Molecular and Integrative Physiology
Associate Professor Emerita of Biophysics
Associate Professor Emerita of Neuroscience

Education

B.S. 1969 Columbia University
Ph.D. 1972 University of Pennsylvania
Postdoc. 1972-1973 Columbia University
Postdoc. 1974-1977 University College, London

Nuclear magnetic resonance spectroscopic (NMRS) studies of living systems

My laboratory uses nuclear magnetic resonance spectroscopy and spectroscopic imaging to study the relationship between metabolism and function in living systems as simple as cells in culture and as complex as human subjects. Studies of isolated tissues include the effect of temperature on the sodium/potassium pump in red blood cells, photic stimulation of toad retina, the control of function and metabolism in amphibian smooth muscle, the mechanism of fatigue in skeletal muscle undergoing servo-controlled isovelocity shortening, and the effects of diseases of pregnancy and gynecologic disorders on the human uterus and placenta. Non-invasive studies in animals and humans include mapping of the distribution of metabolites in skeletal muscle and brain, studies of developmental changes, and studies of the metabolic effects of activity. In each case, we are using NMRS techniques to study specific processes within the context of a complete living system. The aims are to validate new NMRS methods, to elucidate tissue-specific mechanisms, and to draw conclusions concerning basic concepts and design in tissue metabolism and function.

Representative Publications

Damon, B.M., Gregory, C.D., Hall, K.L., Stark, H.J., Gulani, V. and Dawson, M.J. (2002) "Intracellular acidification and volume increases explain R(2) decreases in exercising muscle," Magn. Reson. Med., 47:14-23. [Abstract]

Gardner, J.R., Hess, C.P., Webb, A.G., Tsika, R.W., Dawson, M.J. and Gulani, V. (2001) "Magnetic resonance microscopy of morphological alterations in mouse trabecular bone structure under conditions of simulated microgravity," Magn. Reson. Med., 45:1122-5. [Abstract]

Hsu, A.C. and M.J. Dawson. (2000) "Accuracy of 1H and 31P MRS analyses of lactate in skeletal muscle," Magn. Reson. Med., 44:418-26. [Abstract]

Kmiecik, J.A., Gregory, C.D., Liang, Z.P., Lauterbur, P.C. and Dawson, M.J. (1999) "Lactate quantitation in a gerbil brain stroke model by GSLIM of multiple-quantum-filtered signals. Generalized spectral localization by imaging," J. Magn. Reson. Imaging, 9:539-43. [Abstract]

Yang, Y., Xu, S., Dawson, M.J. and Lauterbur, P.C. (1997) "Diffusion measurement in phantoms and tissues using SLIM localization," J. Magn. Reson., 129:161-164. [Abstract]

Complete Publications List