Stephanie Ceman

sceman@illinois.edu

423 Medical Sciences Building
Office: (217) 244-6793
Lab: (217) 244-6749
Fax: (217) 244-1648

Mail to: Dept. of Cell and Developmental Biology
University of Illinois
B107 CLSL
601 S. Goodwin Avenue
Urbana, IL 61801
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Stephanie Ceman

Associate Professor of Cell and Developmental Biology

Research Topics

Neurobiology, Protein-Nucleic Acid Interactions, Regulation of Gene Expression

Education

B.S., University of Wisconsin-Madison (Bacteriology)
Ph.D., University of Wisconsin-Madison (Genetics)
Postdoctoral fellow, University of Chicago
Postdoctoral fellow, Emory University


Teaching Interests

BMS 603 - Medical Genetics


Teaching Interests

Molecular basis of disease, post-translational modifications, regulation of RNA expression, RNA-protein interactions

The fragile X mental retardation protein FMRP is required for normal cognition: when it is absent, the most common form of inherited mental retardation, fragile X syndrome (FXS) results. Thus, FMRP is a molecular entry point for understanding normal neuronal function. FMRP is an RNA binding protein that binds ~4% of brain mRNAs and regulates their expression—either enhancing or suppressing translation by an unknown mechanism. Many of the mRNAs that bind FMRP have been identified; however, it is still unknown how FMRP regulates their translation. Our long-term goal is to uncover the mechanism of FMRP-mediated translation regulation, exploring both associated proteins and microRNAs.

Representative Publications

Skariah, G., Seimetz, J., Norsworthy, M., Lannom, M.C., Kenny, P. J., Elrakhawy, M., Forsthoefel, C., Drnevich, J., Kalsotra, A., Ceman. S. (2017). Mov10 suppresses retroelements and regulates neuronal development and function in developing brain. BMC Biology. 15(1):54 PMID:28662698

Kenny, P. J. and Ceman, S. 2016. RNA secondary structure modulates FMRP’s bi-functional role in the microRNA pathway. International Journal of Molecular Sciences.17(6): pii: E985

Kenny, P.J., Zhou, H., Kim, M., Skariah, G., Khetani, R.S., Drnevich, J., Arcila, M.L., Kosik, K.S., Ceman, S. 2014. MOV10 and FMRP Regulate AGO2 Association with MicroRNA Recognition Elements. Cell Rep. 9(5): 1729-41

Kim, M. and S. Ceman. 2012. Fragile X Mental Retardation Protein: Past, Present and Future. Current Protein & Peptide Science. 13: 358-371

Blackwell, E. and Ceman, S. 2012. Arginine methylation of RNA binding proteins regulates cell function and differentiation. Molecular Reproductive Physiology.79:163-175

Winograd, C. and Ceman, S. 2011. Fragile X family members have important and non-overlapping functions. Biomolecular Concepts. Oct 1;2(5):343-52

Blackwell. E. and Ceman, S. 2011. Novel regulatory function of region proximal to RGG box in Fragile X Mental Retardation Protein. J. Cell Science. 124: 3060-3065.

Ceman, S. and Saugstad, J. 2011. MicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human disease. Pharmacology and Therapeutics. 130(1): 26-37.

Cheever, A., Blackwell, E., Ceman, S. 2010. Fragile X protein family member FXR1P is regulated by microRNAs. RNA.18 (8): 1530-1539

Blackwell, E. , Zhang, X. and Ceman, S. 2010. Arginines of the RGG box regulate FMRP association with polyribosomes and mRNA. Hum. Mol. Gen.. 19(7): 1314-1323. PMC2838539.

Cheever, A. and Ceman. S. 2009. Phosphorylation of FMRP inhibits association with Dicer. RNA. 15(3): 362-366.

Complete Publications List