William M Brieher

Associate Professor of Cell and Developmental Biology

Research Topics

Cell-Cell Interactions, Cytoskeleton

Education

Ph.D. University of California, San Francisco
Postdoc. Harvard Medical School

Cytoskeleton and Cell Adhesion

Our lab is interested in understanding how cells organize an actin cytoskeleton. Current projects focus on how actin filaments are assembled at cell-cell adhesive junctions, how actin filaments disassemble, and how signals trigger actin assembly. We use a combination of biochemical, biophysical, and cell biological techniques to address these questions which are fundamental for understanding cell shape, cell motility, and morphogenesis. Some of our research provides insight into the molecular basis of inherited kidney disease.

Representative Publications

Yu-Kemp HC, Brieher WM. 2016. Collapsin Response Mediator Protein-1 Regulates Arp2/3-dependent Actin Assembly. J Biol Chem. 291:658-64.

Nadkarni AV, Brieher WM. 2014. Aip1 destabilizes cofilin-saturated actin filaments by severing and accelerating monomer dissociation from ends. Curr Biol. 24:2749-57.

Brieher W. 2013. Mechanisms of actin disassembly. Mol Biol Cell. 24:2299-302.

Tang VW, Brieher WM. 2013. FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions. J Cell Biol. 203:815-833.

Normoyle KP, Brieher WM. 2012. Cyclase Associated Protein (CAP) Acts Directly on F-actin to Accelerate Cofilin-Mediated Actin Severing Across the Range of Physiological pH. J. Biol. Chem. 287:35722-32.

Tang VW, Brieher WM. 2012. α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction. J Cell Biol. 196:115-30.

Complete Publications List