William M Brieher

Associate Professor of Cell and Developmental Biology

Research Topics

Cell-Cell Interactions, Cytoskeleton

Education

Ph.D. University of California, San Francisco
Postdoc. Harvard Medical School

Cytoskeleton and Cell Adhesion

Our lab is interested in on how cells organize an actin cytoskeleton. Current projects focus on how actin filaments are assembled at cell-cell junctions, how actin filaments depolymerize, and how signals trigger actin nucleation. We use a combination of biochemical, biophysical, and cell biological techniques to address these questions which are fundamental for understanding cell shape, cell motility, and morphogenesis.

Representative Publications

Tang VW, Brieher WM. 2013. FSGS3/CD2AP is a barbed-end capping protein that stabilizes actin and strengthens adherens junctions. J Cell Biol. 203:815-833.

Normoyle KP, Brieher WM. 2012. Cyclase Associated Protein (CAP) Acts Directly on F-actin to Accelerate Cofilin-Mediated Actin Severing Across the Range of Physiological pH. J. Biol. Chem. 287:35722-32.

Tang VW, Brieher WM. 2012. α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction. J Cell Biol. 196:115-30.

Kueh, H.Y., Charras, G.T., Mitchison, T.J., and Brieher, W.M. 2008. Actin filaments disassemble in abrupt bursts controlled by barbed-end regulators. J Cell Biol. 182:341-53.

Brieher, W.M., Kueh, H.Y., Ballif, B.A., and Mitchison, T.J. 2006. Rapid actin monomer–insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. J. Cell Biol., 175:315–24.

Complete Publications List