News Archive – 2012

Elena Zelin receives an American Heart Postdoctoral Fellowship

Dr. Elena Zelin, a postdoctorate fellow in Brian Freeman's laboratory, is a recipient of an American Heart Association Postdoctoral Fellowship. This 2 year award is established by the American Heart Association to recognize research accomplishments by outstanding post-doctorates and provide support to continue...

December 13, 2012


Team finds a new way to inhibit blood clotting and inflammation

Corresponding author Professor of Biochemistry James Morrissey and colleagues have identified a group of small molecules that interfere with the activity of a compound that initiates multiple steps in blood clotting, including those that lead to the obstruction of veins...

November 05, 2012


Using planarian flatworms to understand organ regeneration

In a new study published in the October 16 issue of Developmental Cell, corresponding author Professor of Cell and Developmental Biology and Howard Hughes Medical Institute Investigator Phillip Newmark and colleagues report the identification of genes that control growth and regeneration of the intestine...

October 24, 2012


The unanticipated complexity of the selectivity-filter glutamates of nicotinic receptors

In a new finding published in Nature Chemical Biology, Research Scientist Gisela Cymes and Associate Professor of Molecular and Integrative Physiology, Biophysics, and Neuroscience Claudio Grosman applied single-molecule electrophysiology to elucidate the properties of the ring of acidic side chains that...

October 14, 2012


The p23 Molecular Chaperone and GCN5 Acetylase Jointly Modulate Protein-DNA Dynamics

An in-depth understanding of any machine requires classification of the individual parts, knowledge on how the components connect, and recognition of the mechanisms propelling the assembled pieces into a running unit. As biologist we have made admirable progress in naming...

October 04, 2012


The p23 Molecular Chaperone and GCN5 Acetylase Jointly Modulate Protein-DNA Dynamics and Open Chromatin Status

Associate Professor of Cell and Developmental Biology and Alexander von Humboldt Scholar Brian Freeman and colleagues have published "The p23 Molecular Chaperone and GCN5 Acetylase Jointly Modulate Protein-DNA Dynamics and Open Chromatin Status" in Molecular Cell.

October 03, 2012


IN OBESITY, A MICRO-RNA CAUSES METABOLIC PROBLEMS

A team including corresponding author Associate Professor of Molecular and Integrative Physiology Jongsook Kim Kemper has identified a key molecular player in a chain of events in the body that can lead to fatty liver disease, Type II diabetes and other metabolic abnormalities associated...

September 21, 2012


Michelle Wegscheid Receives ASM Undergraduate Research Fellowship

The American Society for Microbiology (ASM) has selected Michelle Wegscheid, a senior in the Specialized Curriculum in Biochemistry, as a 2012 award recipient of the ASM Undergraduate Research Fellowship.

September 21, 2012


Phillip Newmark named University Scholar

Professor of Cell and Developmental Biology and Howard Hughes Medical Investigator Phillip Newmark is among seven university faculty named a University Scholar.

September 11, 2012


Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons

Although cellular metabolic (redox) state has long been associated with a housekeeping role, recent research from a team lead by Martha Gillette, and including the Lee Cox and Jonathan Sweedler groups, provides new insights on cellular redox states, linking...

September 02, 2012


Synthesis of Methylphosphonic Acid by Marine Microbes: A Source for Methane in the Aerobic Ocean

Professor of Microbiology William Metcalf is lead author on a new study of ocean methane in Science. Up to 4 percent of the methane on Earth comes from the ocean’s oxygen-rich waters, but scientists have been...

August 31, 2012


A Gain-of-Function Polymorphism Controlling Complex Traits and Fitness in Nature

Professor of Cell and Developmental Biology and Biochemistry Mary Schuler and colleagues have published a new study in Science.

August 30, 2012


Interacting cellular oscillators of the brain’s circadian clock

Although cellular metabolic (redox) state has long been associated with a housekeeping role, recent research from a team lead by Martha Gillette, and including the Lee Cox and Jonathan Sweedler groups, provides new insights on cellular redox states, linking them to the intrinsic...

August 27, 2012


Molecular basis of bacterial protein Hen1 activating the ligase activity of bacterial protein Pnkp for RNA repair

Associate Professor of Biochemistry Raven Huang and colleagues have published "Molecular basis of bacterial protein Hen1 activating the ligase activity of bacterial protein Pnkp for RNA repair" in the Proceedings of the National Academy...

August 07, 2012


Circadian Rhythm of Redox State Regulates Excitability in Suprachiasmatic Nucleus Neurons

Tongfei Wang, Gubbi Govindaiah, Liana Artinian, and Charles Cox of the Department of Molecular and Integrative Physiology are co-authors of a new paper in Sciencexpress. Professor of Molecular and Integrative Physiology and Cell and Developmental Biology Martha Gillette is corresponding...

August 03, 2012


Labib Rouhana selected to the Summer Leadership Institute

Labib Rouhana, a postdoctoral researcher in the laboratory of Dr. Phil Newmark, has been awarded the prestigious Ford Foundation Postdoctoral Fellowship.

July 25, 2012


A protease for 'middle-down' proteomics

Cong Wu, a graduate student in the Department of Biochemistry, is the first author on "A protease for 'middle-down' proteomics" in Nature Methods.

June 25, 2012


James H. Morrissey Appointed Roy and Eva Hong Professor of Molecular and Cellular Biology

Professor of Biochemistry James H. Morrissey has been appointed as the Roy and Eva Hong Professor of Molecular and Cellular Biology.

June 19, 2012


First ASCB Graduate Student/Postdoc-Initiated Minisymposium: Cell Biology of Regeneration

Rachel Roberts-Galbraith, postdoc in Cell and Developmental Biology, is co-chair of "Cell Biology of Regeneration," the winning topic in the competition to organize the 2012 American Society for Cell Biology Graduate Student/Postdoc-Initiated Minisymposium.

June 17, 2012


Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast cancer

Assistant Professor of Biochemistry and Medical Biochemistry at the College of Medicine Lin-Feng Chen is corresponding author on a new study on RUNX3, a tumor suppressor in breast cancer.

May 15, 2012


Accelerating Membrane Insertion of Peripheral Proteins with a Novel Membrane Mimetic Model

Emad Tajkhorshid is corresponding author on "Accelerating Membrane Insertion of Peripheral Proteins with a Novel Membrane Mimetic Model," selected as the feature cover article in the May 2 issue of Biophysical Journal.

May 13, 2012


Yejing Ge receives the Procter & Gamble Award

Yejing Ge, a graduate student in Jie Chen Lab, is the recipient of the 2012 Procter & Gamble Graduate Student Research Award.

May 13, 2012


Tyler Moran selected as the 2011 recipient of the Molecular Endocrinology Student Author Award

Tyler Moran, Ph.D., who completed his thesis in the lab of Assistant Professor of Molecular and Integrative Physiology Lori Raetzman, was selected as the 2011 recipient of the Molecular Endocrinology Student Author Award.

May 10, 2012


Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts

In a new study, Assistant Professor of Molecular and Integrative Physiology Kevin Xiang and colleagues show that the PGE2 stimulation attenuates the adrenergic-induced cardiac contractile response in animal hearts.

April 09, 2012


Rachel Smith-Bolton Receives Carver Charitable Trust Award

Assistant Professor of Cell and Developmental Biology Rachel Smith-Bolton has been awarded the highly competitive 3-year Carver Young Investigator Award. The award pays $300,000 over three years.

April 03, 2012


Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

Corresponding author Professor of Molecular and Integrative Physiology Claudio Grosman, Associate Professor of Biochemistry Satish Nair, and colleagues have published new work in PNAS.

April 02, 2012


Extension of the Cellular Molecular Chaperone Network

The eukaryotic molecular chaperone network is formed by the concerted actions of Hsp90, Hsp70 and their associated cochaperones. Typically, cochaperones had been considered regulatory factors that modulate the ATPase activities of Hsp90 and Hsp70 and also guide these chaperone to distinct clients. In this...

March 28, 2012


Phil Newmark appointed as a Romano Scholar

Associate Professor of Cell and Developmental Biology and Howard Hughes Medical Institute Investigator Phillip Newmark, has been appointed as a Richard and Margaret Romano Professorial Scholar. The appointment is for a three-year term and will provide a discretionary fund of $25,000 per annum to...

March 28, 2012


Mechanism of Actin Nucleation at Adherens Junctions

The cells comprising all solid tissues in our bodies are held together by a family of adhesion molecules known as cadherins. A network of intracellular fibers known as actin strengthens the adhesive contact, but the molecular mechanisms connecting actin filaments to cadherins are poorly...

March 28, 2012


Team discovers how bacteria resist a 'Trojan horse' antibiotic

A new study led by Associate Professor of Biochemistry Satish Nair describes how bacteria use a previously unknown means to defeat an antibiotic.

March 20, 2012


Molecular Determinants of Scouting Behavior in Honey Bees

There is novelty-seeking behavior, across different contexts, among honey bees in their tendency to scout for food sources and nest sites.

March 14, 2012


Msx Homeobox Genes Critically Regulate Embryo Implantation

A unique signaling network regulated by the homeobox transcription factors MSX1 and MSX2 in the mouse uterus critically controls female fertility.

February 28, 2012


Team Discovers Microbes Speciating

Not that long ago in a hot spring in Kamchatka, Russia, two groups of genetically indistinguishable microbes parted ways. They began evolving into different species – despite the fact that they still encountered one another in their acidic, boiling habitat and even exchanged some genes from time...

February 22, 2012


Cancer Research Forum and Poster Prize Competition

All faculty, fellows, students and investigators are invited to present posters on cancer-related research in basic, clinical, and translational areas of investigation.

February 01, 2012


Phylogeny and beyond: Scientific, historical, and conceptual significance of the first tree of life

A fundamental breakthrough in biological science occurred in 1977, and most biologists did not notice: a paper by Professor of Microbiology Carl Woese that compared sequence snippets derived from small subunit rRNAs of different organisms.

January 31, 2012


Attack or retreat? Circuit links hunger and pursuit in sea slug brain

In a new study, Professor of Molecular and Integrative Physiology Rhanor Gillette reports on a circuit in the brain of the sea slug Pleurobranchaea.

January 31, 2012


Building up actin at adherens junctions

Assistant Professor of Cell and Developmental Biology William Brieher and Vivan Tang have published "α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction" in the Journal of Cell Biology.

January 18, 2012


Let's Do The Twist: Spiral Proteins are Effective Gene Delivery Agents

Illinois researchers developed spiral polypeptides that can deliver DNA segments to cells with high efficiency and relatively low toxicity, a step toward clinical gene therapy. The team, from left, postdoctoral researchers Lichen Yin and Dong Li; Fei Wang, a professor...

January 04, 2012