Researchers identify protein essential for embryo implantation
A research article, communicated jointly by Professor of Molecular and Integrative Physiology Milan Bagchi, and Professor of Comparative Biosciences Indrani Bagchi, has been published in the journal Science. In this paper, researchers at the NIH-funded Center of Research in Reproduction at the University of Illinois address an important unresolved issue in steroid hormone biology: the mechanism by which progesterone counteracts estrogen-induced uterine growth. The antiproliferative action of progesterone in the uterus is of high clinical significance since breakdown of this action underpins female infertility as well as estrogen-driven hyperplasia and endometrial cancer.
Team solves decades-old molecular mystery linked to blood clotting
An interdisciplinary collaboration at the University of Illinois led to a breakthrough in understanding blood clotting. Researchers on the study were (from left): Emad Tajkhorshid, Chad Rienstra, Mary Clay, Rebecca Davis-Harrison, Zenmei Ohkubo, Narjes Tavoosi, Mark Arcario, Taras Pogorelov and James Morrissey.
Team identifies new breast cancer tumor suppressor and how it works
In a new study, Assistant Professor of Biochemistry Lin-Feng Chen and colleagues identified a new breast cancer tumor suppressor protein, Runx3, and determined how it functioned.
Small change makes a big difference for ion channels
Associate Professor of Molecular and Integrative Physiology Claudio Grosman and research scientist Gisela Cymes used a high-resolution single-molecule study technique to see the very subtle differences between two branches of an important family of neurotransmitter-gated ion channels.
Team discovers how a cancer-causing bacterium spurs cell death
A new study led by Professor of Microbiology Stephen Blanke, in Proceedings of the National Academy of Sciences, is the first to show how a bacterial toxin can disrupt a cell’s mitochondria – its energy-generation and distribution system – to disable the cell and spur apoptosis (programmed cell death).