Highlights

Study reveals a novel target for the treatment of breast cancer

Image Caption: Treatment with the drug pimozide reduced tumor growth in a mouse model of breast cancer. Immunohistochemistry for phosphorylated (active) STAT5 and total STAT5 protein indicates that activation of STAT5 signaling is inhibited by pimozide treatment in vivo. Adapted from Mapes, et al. (Journal of Biological Chemistry 2018).

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Professional development workshop aimed at empowering women for successful careers

MCB faculty and staff presented strategies for success at the recent Women's Career Institute event held on February 24, 2018.

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Virtual predator is self-aware, behaves like living counterpart

Rhanor Gillette and his colleagues built a virtual ocean predator that has simple self-awareness.

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Cronan Lab: Lipoyl transfer has a "moonlighting" function -- that is, development of a new function while retaining the original function

The study's findings were recently published in PNAS

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Engineering T cells to attack cancer

The Kranz lab and colleagues have recently publish a trio of papers that describe the engineering of receptors that can mediate specific and potent destruction of cancers by T cells.

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Researchers identify new physiological regulators of the one carbon cycle metabolism. The findings were published in Nature Communications.

Professor of Molecular and Integrative Physiology, Jongsook Kim Kemper and the first and co-corresponding author, Young Kim, co-author Sangwon Byun, and colleagues demonstrated that Aromatic Hydrocarbon Receptor (AHR) and the orphan nuclear receptor, Small Heterodimer Partner (SHP), have an unexpected function in regulating one carbon (1C) metabolism in the fed-state. Dysregulation of the 1C metabolism by the AHR-SHP axis leads to metabolic problems like fatty liver disease.

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Chung Lab: Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.

New findings suggest that novel down-regulation of GIRK channels by caspase-3 may contribute to NMDAR-dependent hippocampal atrophy following chronic epileptic seizures

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Bacterial chromosomal breakdown during isolation highlights the unusual regulation of the surface nucleases

A recent paper in PLOS ONE from the Kuzminov lab illustrated a novel phenomenon, RiCF, aka “RNase-induced chromosomal fragmentation.”

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Social experience tweaks genome functionbehavior

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Social experience tweaks genome function, behavior

In a recent Genome Research publication, Stubbs and her colleagues identified and documented the activity of networks of genes involved in the response to social stress.

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Brooke Lab: Certain Flu Virus Mutations May Compensate for Fitness Costs of Other Mutations

New research published in PLOS Pathogens finds that unexpected mutations help flu virus retain fitness by counteracting changes needed to dodge the immune system

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Dr. Craig Mizzen, Associate Professor of Cell and Developmental Biology, passed away at his home on January 5, 2018, after a long and heroic battle with cancer. He was 61.

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Remembering Dr. Craig Mizzen

Dr. Craig Mizzen, Associate Professor of Cell and Developmental Biology, passed away at his home on January 5, 2018, after a long and heroic battle with cancer. He was 61.

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Microbiology alumna wins the 2018 Breakthrough Prize in Life Sciences

Joanne Chory (PhD Microbiology '84) is currently a plant biologist at the Salk Institute for Biological Sciences.

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The Grosman and Tajkhorshid labs collaborate on "Chasing the open-state structure of pentameric ligand-gated ion channels." Their findings are presented as the cover story in the December Issue of The Journal of General Physiology.

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The Grosman and Tajkhorshid labs collaborate on "Chasing the open-state structure of pentameric ligand-gated ion channels." Their findings are presented as the cover story in the December Issue of The Journal of General Physiology.

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MCB graduate students present "Science on Tap"

The MCB Graduate Student Association (GSA), known as the MCBees, inaugurated a new outreach event, “Science on Tap,” on Sunday, November 19, 2017. Zach Costliow (Degnan Lab) presented, “Homebrewed Vitamins: What B1 and B. thetaiotaomicron are doing in your gut” at Riggs in Urbana.

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The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling

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Alumnus Thomas Cycyota Receives American Association of Tissue Banks Award

Cycyota received the Jeanne C. Mowe Distinguished Service Award, which recognizes an individual who has made a significant contribution in tissue banking or transplantation, whether in research, education, or laboratory improvement, or who has served the Association or the field of tissue banking.

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Alumnus Thomas Cycyota Receives American Association of Tissue Banks Award

Cycyota received the Jeanne C. Mowe Distinguished Service Award, which recognizes an individual who has made a significant contribution in tissue banking or transplantation, whether in research, education, or laboratory improvement, or who has served the Association or the field of tissue banking.

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Satish Nair named I.C. Gunsalus Professor in the College of Liberal Arts & Sciences

Nair, a professor of biochemistry in the School of Molecular and Cellular Biology and director of the Center for Biophysics and Quantitative Biology, is a leader in studying how bacteria can make antibiotics and other medicinally relevant molecules.

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The School of MCB wishes to reiterate the sentiments of Chancellor Jones, "Intolerance, racism and violence...will never be condoned" in MCB or at Illinois.

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Brooke lab and colleagues working to develop evolving antiviral therapeutics

The Defense Advanced Research Projects Agency (DARPA) is funding the multi-investigator group focusing on eliminating influenza virus.

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Study identifies two proteins necessary for epithelial cell-cell junctions

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Cell and Developmental Biology graduate student Yu-Kemp and colleagues identify two proteins necessary for epithelial cell-cell junctions

The work is the cover story of the August issue of The Journal of Cell Biology.

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The program aims to form new insights on the brain and expand participation in field of brain science.

The National Science Foundation recently granted the University of Illinois $3 million for an interdisciplinary graduate student training program to help form new insight on the brain—and to expand participation in the field of brain science itself.

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NSF awards Illinois $3 million for interdisciplinary graduate student training

Professor Martha Gillette will lead the program to form new insight on the brain and expand participation in field of brain science.

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The Department of Cell and Developmental Biology recognizes her dedication, talent, and effectiveness in teaching.

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Dennis Dalby wins the 2017 Staff Award from the College of Liberal Arts and Sciences

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Professor Jongsook Kemper’s group uncover a nutrient-sensing epigenetic pathway that controls autophagy

Lysosome-mediated autophagy is essential for cellular survival by recycling cytoplasmic components under nutrient-deprived conditions and removing damaged organelles in cells, but must be suppressed in nutrient-rich conditions to prevent unnecessary breakdown of cellular components. Molecular and Integrative Physiology Professor Jongsook Kemper, postdoctoral fellow Sangwon Byun (leading author of the study), research scientist Young Kim, and colleagues identified a new regulatory pathway that epigenetically represses autophagy upon feeding.

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Inhibitory neurons in green and neuron bundles expressing a protein that is triggered by a social experience in red.

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