Highlights Archive

2012

Morrissey313

Team finds a new way to inhibit blood clotting and inflammation

Corresponding author Professor of Biochemistry James Morrissey and colleagues have identified a group of small molecules that interfere with the activity of a compound that initiates multiple steps in blood clotting, including those that lead to the obstruction of veins or arteries, a condition called thrombosis.

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Grosman cymes313

The unanticipated complexity of the selectivity-filter glutamates of nicotinic receptors

In a new finding published in Nature Chemical Biology, Research Scientist Gisela Cymes and Associate Professor of Molecular and Integrative Physiology, Biophysics, and Neuroscience Claudio Grosman applied single-molecule electrophysiology to elucidate the properties of the ring of acidic side chains that catalyzes the flow of cations through the nicotinic acetylcholine receptor channel.

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20121001freeman

The p23 Molecular Chaperone and GCN5 Acetylase Jointly Modulate Protein-DNA Dynamics

An in-depth understanding of any machine requires classification of the individual parts, knowledge on how the components connect, and recognition of the mechanisms propelling the assembled pieces into a running unit. As biologist we have made admirable progress in naming the numerous physical factors constituting cells as well as rendering annotated maps on how these subunits arrange into distinct structures or pathways. Yet, our grasp of the cellular properties sustaining a cell system in an active, working state is limited.

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20120824gillette

Interacting cellular oscillators of the brain’s circadian clock

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Chaperone network

Extension of the Cellular Molecular Chaperone Network

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Actin nucleation

Mechanism of Actin Nucleation at Adherens Junctions

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