Publications

Zhang J, Kim EC, Chen CC, Procko E, Pant S, Lam K, Patel J, Choi R, Hong M, Joshi D, Bolton EC, Tajkhorshid E, and Chung HJ (2020). Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy. Scientific Reports 10, 4756 (2020). https://doi.org/10.1038/s41598-020-61697-6.

Liu J, Li F, Wang Y, Pan L, Lin P, Zhang B, Zheng Y, Xu Y, Liao H, Ko G, Fei F, Xu C, Du Y, Shin K, Kim D, Jang SS, Chung HJ, Tian H, Wang Q, Guo W, Nam JM, Chen Z, Hyeon TH, Ling D. A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain. Nature Nanotechnology, In Press.

Brill AL, Fischer TT, Walters JM, Marlier A, Sewanan LR, Wilson PC, Johnson EK, Moeckel G, Cantley LG, Campbell SG, Nerbonne JM, Chung HJ, Robert ME, Ehrlich BE (2020). Polycystin 2 is increased in disease to protect against stress-induced cell death. Scientific Reports, 2020 Jan 15;10(1):386. PMID: 31941974

Kim EC, Patel J, Zhang J, Soh H, Rhodes JS, Tzingounis A, and Chung HJ. (2019). Heterozygous loss of epilepsy gene KCNQ2 alters social, repetitive, and exploratory behaviors. Genes, Brain, and Behavior. 2019 Jul 8:e12599. PMID: 31283873 ***Highlighted in Dept. of Molecular and Integrative Physiology Website. http://mcb.illinois.edu/news/article/525/

Ballance WC, Qin EC, Chung HJ, Gillette MU, and Kong HJ (2019). Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases. Biomaterials, Volume 217, October 2019, 119292. https://doi.org/10.1016/j.biomaterials.2019.119292 

Le P, Lim SJ, Baculis BC, Chung HJ, Kilian KA, and Smith AM. (2019). Counting growth factors in single cells with infrared quantum dots to measure discrete stimulation distributions. Nat Commun. 2019 Feb 22;10(1):909. PMID: 30796217 PMCID: PMC6385258

Kim EC, Zhang J, Pang W, Wang S, Lee KY, Cavaretta, JP, Walters J, Procko E, Tsai N-P-, and Chung HJ. (2018). Reduced axonal surface expression and phosphoinositide sensitivity in Kv7 channels disrupts their function to inhibit neuronal excitability in Kcnq2 epileptic encephalopathy. Neurobiology of Disease. 2018 Oct;118:76-93. PMID: 30008368.                            ***Highlighted in Dept. of Molecular and Integrative Physiology Website. http://mcb.illinois.edu/news/article/494/

Kim IJ, Lee J, Oh SJ, Yoon MS, Jang SS, Holland RL, Reno ML, Hamad MN, Maeda T, Chung HJ, Chen J, Blanke SR. (2018). Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1. Cell Host Microbe. 2018, May 9;23(5):583-593.e8. PMID: 29746831.

Lee KY, Jewett KA, Chung HJ, Tsai NP. (2018). Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2. Human Molecular Genetics, 2018 Aug 15;27(16):2805-2816. PMID: 29771335

Baculis BC*, Weiss AC*, Pang W*, Jeong HG, Lee JH, Liu DC, Tsai NP, and Chung HJ (2017). Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels. Scientific Reports, 2017 Sep 26;7(1):12313. PMID: 28951616                                                                                                                               ***Highlighted in Dept. of Molecular and Integrative Physiology Website. http://mcb.illinois.edu/news/article/468/

Liu DC, Seimetz J, Lee KY, Kalsotra A, Chung HJ, Lu H, and Tsai NP (2017). Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity. Human Molecular Genetics, 2017 Oct 15;26(20):3895-3908.

Jang S, Jeong H, Chung HJ (2017). Electroconvulsive seizures in rats and fractionation of their hippocampi to examine seizure-induced changes in postsynaptic density proteins. Journal of Visualized Experiments, 2017 Aug 15;(126). doi: 10.3791/56016. PMID:28829421

Zhu J, Lee KY, Jewett KA, Man H, Chung HJ, Tsai N-P- (2017). Epilepsy-associated gene Nedd4-2 mediates neuronal network activity and seizure susceptibility through AMPA receptors. PLOS Genetics, 2017 Feb 17;13(2):e1006634, PMID:28212375

Vega L JC, Lee MK, Qin EC, Lee KY, Chung HJ, Leckband DE, Kong H (2016). Three dimensional conjugation of recombinant N-Cadherin to a hydrogel for in vitro anisotropic neural growth. Journal of Materials Chemistry B Materials for Biology and Medicine, 4(42):6803-6811. PMCID: PMC5423733

Jang S*,  Royston SE*, Gunhee Lee#, Shuwei Wang#, and Chung HJ (2016). (*These authors contributed equally; #These authors contributed equally). Seizure-induced regulations of amyloid-beta, STEP61, and STEP61 substrates involved in hippocampal synaptic plasticity. Neural Plasticity. vol. 2016, Article ID 2123748, 13 pages, 2016. doi:10.1155/2016/2123748PMCID: PMC4835651.

Jang S and Chung HJ (2016). Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity. Neural Plasticity. vol. 2016, Article ID 7969272, 19 pages, 2016. doi:10.1155/2016/7969272.

Jang S*,  Royston SE*, Xu J, Cavaretta JP, Vest MO, Lee KY, Lee S, Jeong H, Lombroso PJ, and Chung HJ (2015). Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity. Molecular Brain. Sep 22;8(1):55. PMCID: PMC4578242.

Lee K*, Royston SE*, Vest MO, Ley DJ, Lee S, Bolton EC, and Chung H (2015). (*These authors contributed equally). N-methyl-D-aspartate Receptors mediate Activity-dependent Down-Regulation of Potassium Channel Genes during the Expression of Homeostatic Intrinsic Plasticity. Molecular Brain. 8(1):4PMCID: PMC4333247.

Wang Y, Cai E, Rosenkranz T, Ge P, Teng KW,  Lim SJ, Smith A,
Chung HJ, Sachs F, Sachs F, Green W, Gottlieb P, and  Selvin PR (2014). Small Quantum Dots Conjugated to Nanobodies as Immunofluorescence Probes for Nanometric Microscopy. Bioconjugate Chemistry. 25(12):2205-11. PMCID: PMC4275168.

Cai E, Ge P, Lee SH, Jeyifous O, Wang Y, Liu Y, Wilson KM, Lim SJ, Baird MA, Stone JE, Lee KY, Davidson MW, Chung HJ, Schulten K, Smith AM, Green WN, Selvin PR. (2014). Stable small quantum dots for synaptic receptor tracking on live neurons. Angewandte Chemie, 53(46):12484-8. PMCID: PMC4240739.

Lee KY and Chung HJ (2014). NMDA receptors and L-type voltage-gated Ca2+ channels mediate the Expression of Bidirectional Homeostatic Intrinsic Plasticity in Cultured Hippocampal Neurons. Neuroscience. (277):610-23 10.1016/j.neuroscience.2014.07.038. PMID: 25086314.

Cavaretta JP*, Sherer KS*, Lee KY, Issema RS, Kim EH, and Chung HJ (2014). (*These authors contributed equally). Polarized Axonal Surface Expression of Neuronal KCNQ Potassium Channels is Regulated by Calmodulin Interaction with KCNQ2 Subunit. PLos One, 9(7):e103655. DOI:10.1371/journal.pone.0103655PMCID: PMC4117524.         

Chung HJ (2014). Role of calmodulin in neuronal Kv7/KCNQ potassium channels and epilepsy. Frontiers in Biology. 9(3):205-15.

Vega L JC, Lee MK, Jeong JH, Smith CE, Lee KY, Chung HJ, Leckband DE, Kong H. (2014). Recapitulating cell-cell adhesion using N-Cadherin biologically tethered to substrates. Biomacromolecules.  15(6):2172-9. PMID: 24773064.

Hearing M, Kotecki L, Marron Fernandez de Velasco E, Fajardo-Serrano A, Chung HJ, Luján R, Wickman K. (2013). Repeated Cocaine Weakens GABAB-Girk Signaling in Layer 5/6 Pyramidal Neurons in the Prelimbic Cortex. Neuron 80(1):159-70. PMCID: PMC3793643.

Chung HJ*, Lee HK* (2009). Constructing a road map from synapses to behaviour. Meeting on Synapses: From Molecules to Circuits & Behavior. (*These authors contributed equally to this work). EMBO Rep.,10(9):958-62. PMCID: PMC2750071.

Chung HJ*, Woo-ping Ge*, Xiang Qian, Ofer Wiser, Jan YN, and Jan LY (2009). G-protein activated inwardly rectifying potassium channels mediate depotentiation of long-term potentitation. (*These authors contributed equally to this work). Proc Natl Acad Sci U S A, 106(2): 635-40. PMCID: PMC2613041.

Chung HJ, Xiang Qian, Melissa Ehlers, Jan YN, and Jan LY (2009). Neuronal activity regulates phosphorylation-dependent surface delivery of G-protein activated inwardly rectifying potassium channels. Proc Natl Acad Sci U S A, 106(2): 629-34. PMCID: PMC2613039.

Chung HJ, Jan YN, and Jan LY (2006). Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc Natl Acad Sci U S A, 103 (23): 8870-5. PMCID: PMC1472242.

Chung HJ, Lau LF, Huang YH and Huganir RL (2004). Regulation of NMDA Receptor complex and trafficking by activity-dependent phosphorylation of NR2B subunit PDZ ligand. J Neurosci, 24(45):10248-59.

Heynen AJ, Yoon BJ, Liu CH, Chung HJ, Huganir RL and Bear MF (2003). Molecular mechanism for loss of visual cortical responsiveness following brief monocular deprivation. Nat Neurosci. 6(8):854-62.

Chung HJ*, Steinberg JP*, Huganir RL, Linden DJ (2003). Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. (*These authors contributed equally to this work). Science, 300(5626):1751-5.

McDonald BJ, Chung HJ, and Huganir RL (2001). Identification of Protein Kinase C phosphorylation sites within the AMPA receptor GluR2 subunit. Neuropharmacology, 41(6):672-679.

Kim CH*, Chung HJ*, Lee H-K-, and Huganir RL (2001). Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long term-depression. (*These authors contributed equally to this work). Proc Natl Acad Sci U S A, 98(20):11725-30. PMCID: PMC58797.

Xia J, Chung HJ, Wihler C, Huganir RL, and Linden DJ (2000). Cerebellar long-term depression requires PKC-regulated interactions between GluR2/3 and PDZ domain-containing proteins. Neuron, 28(2):499-510.

Chung HJ, Xia J, Scannevin RH, Zhang X, and Huganir RL (2000). Phosphorylation of the AMPA receptor subunit GluR2 differentially regulates its interaction with PDZ domain-containing proteins. J Neurosci, 20(19):7258-67.