Joanna L. Shisler
PROGRAM DIRECTOR AT THE NATIONAL SCIENCE FOUNDATION
AFFILIATE, DEPARTMENT OF MICROBIOLOGY
Host-Pathogen Interactions, Virology
Disease Research Interests
B.A. (Microbiology), Miami University, 1990
Ph.D. (Immunology and Molecular Pathogenesis), Emory University, 1996
Postdoctoral (Virology), Laboratory of Viral Diseases, National Institutes of Health, 1997-2001
Immune evasion strategies of viruses; molecular disinfection of viruses; molecular tracking viruses in the environment
Viruses are one of the most abundant microorganisms on the planet, infecting every form of life from humans to bacteria. Mammalian viruses, many of which are zoonotic (i.e., transmitted to humans from other animals), are directly responsible for some of the worst diseases known to man (e.g., Ebola virus, HIV), and for common causes of morbidity and mortality around the world (e.g., norovirus, influenza virus).
Understanding, detecting and controlling viruses continue to be grand challenges in science because so little is known about the fundamental properties of viruses and their interactions with the environment, and because they vary greatly with respect to their genomes and replication cycles.
I am interested in asking fundamental question about virology: What are the molecular properties of viruses that make them resistant or susceptible to disinfection in natural settings versus hospitals or water treatment plants? How do viruses evade the immune system to cause disease? How does the physical environment affect virus evolution and spread?
A cautionary note on the selectivity of oncolytic poxviruses. Tang B, Guo ZS, Bartlett DL, Liu J, McFadden G, Shisler JL, Roy EJ. Oncolytic Virother. 2019 Feb 11;8:3-8. doi: 10.2147/OV.S189832. eCollection 2019. PMID: 30805315
Influence of algal organic matter on MS2 bacteriophage inactivation by ultraviolet irradiation at 220 nm and 254 nm. Wang Y, Araud E, Shisler JL, Nguyen TH, Yuan B. Chemosphere. 2019 Jan;214:195-202. doi: 10.1016/j.chemosphere.2018.09.065. Epub 2018 Sep 17. PMID: 30265926
Inactivation Mechanisms of Human and Animal Rotaviruses by Solar UVA and Visible Light. Araud E, Shisler JL, Nguyen TH. Environ Sci Technol. 2018 May 15;52(10):5682-5690. doi: 10.1021/acs.est.7b06562. Epub 2018 May 3. PMID: 29671592
Adenovirus Replication Cycle Disruption from Exposure to Polychromatic Ultraviolet Irradiation. Vazquez-Bravo B, Gonçalves K, Shisler JL, Mariñas BJ. Environ Sci Technol. 2018 Mar 20;52(6):3652-3659. doi: 10.1021/acs.est.7b06082. Epub 2018 Mar 6. PMID: 29480719
A comparison of the effect of molluscum contagiosum virus MC159 and MC160 proteins on vaccinia virus virulence in intranasal and intradermal infection routes. Biswas S, Smith GL, Roy EJ, Ward B, Shisler JL. J Gen Virol. 2018 Feb;99(2):246-252. doi: 10.1099/jgv.0.001006. PMID: 29393023
Characterizing the effects of insertion of a 5.2 kb region of a VACV genome, which contains known immune evasion genes, on MVA immunogenicity. Ryerson MR, Shisler JL. Virus Res. 2018 Feb 15;246:55-64. doi: 10.1016/j.virusres.2018.01.004. Epub 2018 Jan 16. PMID: 29341877
Cellular FLIP long isoform (cFLIPL)-IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression. Gates-Tanzer LT, Shisler JL. J Biol Chem. 2018 Feb 2;293(5):1745-1755. doi: 10.1074/jbc.RA117.000541. Epub 2017 Dec 8. PMID: 29222334
Voluntary Wheel Running Does Not Alter Mortality to or Immunogenicity of Vaccinia Virus in Mice: A Pilot Study. Pence BD, Ryerson MR, Bravo Cruz AG, Woods JA, Shisler JL. Front Physiol. 2018 Jan 5;8:1123. doi: 10.3389/fphys.2017.01123. eCollection 2017. PMID: 29354074
The Effect of the 2015 Earthquake on the Bacterial Community Compositions in Water in Nepal. Uprety S, Hong PY, Sadik N, Dangol B, Adhikari R, Jutla A, Shisler JL, Degnan P, Nguyen TH. Front Microbiol. 2017 Dec 6;8:2380. doi: 10.3389/fmicb.2017.02380. eCollection 2017. PMID: 29270153
Vaccinia Virus Encodes a Novel Inhibitor of Apoptosis That Associates with the Apoptosome. Ryerson MR, Richards MM, Kvansakul M, Hawkins CJ, Shisler JL. J Virol. 2017 Nov 14;91(23). pii: e01385-17. doi: 10.1128/JVI.01385-17. Print 2017 Dec 1. PMID: 28904196
Molluscum Contagiosum Virus MC159 Abrogates cIAP1-NEMO Interactions and Inhibits NEMO Polyubiquitination. Biswas S, Shisler JL. J Virol. 2017 Jul 12;91(15). pii: e00276-17. doi: 10.1128/JVI.00276-17. Print 2017 Aug 1. PMID: 28515292
Deletion of the K1L Gene Results in a Vaccinia Virus That Is Less Pathogenic Due to Muted Innate Immune Responses, yet Still Elicits Protective Immunity. Bravo Cruz AG, Han A, Roy EJ, Guzmán AB, Miller RJ, Driskell EA, O'Brien WD Jr, Shisler JL. J Virol. 2017 Jul 12;91(15). pii: e00542-17. doi: 10.1128/JVI.00542-17. Print 2017 Aug 1. PMID: 28490586