A protease for 'middle-down' proteomics

Cong Wu, a graduate student in the Department of Biochemistry, is the first author on "A protease for 'middle-down' proteomics" in Nature Methods.

Cong Wu, a graduate student in the Department of Biochemistry, is the first author on "A protease for 'middle-down' proteomics" in Nature Methods. Wu works in the lab of co-author Affiliate Professor of Molecular and Integrative Physiology Jonathan Sweedler. Wu's research advisor, corresponding author Neil Kelleher, was Affiliate Professor of Biochemistry before leaving the University last year.

According to Cong Wu, "This work is about a novel rare-cutting protease-based approach to perform proteomics using mass spectrometry. The protease we report produces larger peptides than traditional proteases and provides complementary biological information. It serves as an attractive option for researchers to conduct mass spectrometry-based proteomic studies."

Read the full text online in Nature Methods

June 25, 2012 All News