News

Colin A. Wraight (1945-2014)

Professor Wraight employed biochemical and biophysical methods to understand how the structure of membrane proteins allowed them to catalyze the transfer of electrons and protons in biological energy conversion, processes fundamental to life on this planet. Born in 1945 in London, UK, he studied at the University of Bristol, earning his BSc in 1967 and his PhD in 1971. After postdoctoral research at the University of Leiden and Cornell University, and a brief faculty position at the University of California at Santa Barbara, he joined the faculty at the University of Illinois at Urbana-Champaign in 1975 as an assistant professor in the Departments of Plant Biology and Physiology & Biophysics. He held many positions during his 39 years on the faculty of our university, including serving as Director of the Center for Biophysics and Computational Biology from 1995-1999. He joined the Biochemistry Department in 1999 and served as Head of Biochemistry from 2004-2009. He also held faculty positions in the Departments of Plant Biology and Molecular & Integrative Physiology. In addition to his important research contributions, Professor Wraight was a passionate teacher and mentor, and an outstanding colleague who gave unselfishly to others. He was known for the breadth and depth of his knowledge, quick wit, and the gracious hospitality that he and his wife, Mary, extended to all. His dedication to teaching and graduate training even during his illness was an inspiration to all who knew him. He is survived by Mary and their children, Lydia, Tristan and Sebastian.

     
Posted July 11, 2014
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Distinguished alumnus, Phillip A. Sharp, receives honorary doctorate at convocation

May, 2014: This spring, the Department of Biochemistry and the School of Molecular and Cellular Biology recognized the accomplishments of one of our most distinguished alumni, Phillip A. Sharp, with an honorary doctorate presented at convocation.

The nomination for this highest of university honors was submitted by Dr. James Morrissey, Acting Head of the Department of Biochemistry. "Professor Sharp's discoveries have fundamentally changed our understanding of gene structure and have opened new areas of research in RNA biology,” said Morrissey. “Professor Sharp also has a distinguished record of public service, and has been a steadfast friend of our department."

Currently an Institute Professor with the Koch Institute for Integrative Cancer Research at MIT, Professor Sharp earned a PhD in Chemistry from the University of Illinois in 1969 and has spent the next 45 years contributing to the study of genetics and molecular biology and the development of the biotechnology industry. His remarkable scientific career led to the discovery of splicing in eukaryotes – a finding that has revolutionized the study of RNA and for which he was awarded the Nobel Prize in Physiology or Medicine in 1993.

One of the founding entrepreneurs of the biotechnology industry, Professor Sharp helped start Biogen in 1978, which later merged with Idec. Now, Biogen Idec focuses on developing drugs for neurodegenerative diseases, hemophilia and autoimmune disorders. Sharp also co-founded Alnylam Pharmaceuticals in 2002 to develop RNAi as a therapeutic.

Gratefully acknowledging that “somebody before me supported this University to make it possible for me to go here,” Professor Sharp and his wife, Ann, endowed a named Professorship in Biochemistry in 2006. The professorship is currently held by Dr. David Kranz, an immunologist in the Department of Biochemistry.

“Having known Phil Sharp for 30 years, since the time I was a postdoctoral fellow at MIT, I have had great respect for his science and his generosity,” said Kranz. “Dr. Sharp has given time and effort to many causes, and it has been a special honor to be the inaugural holder of the Phillip A. Sharp Professorship in Biochemistry.”

The University of Illinois’ School of Molecular and Cellular Biology and the Department of Biochemistry are particularly proud to recognize the many contributions and accomplishments of Dr. Sharp and honor his continued support of scientific exploration.

     
Posted June 30, 2014
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Microbial Diversity – A Tribute to the Life and Work of Abigail Salyers

During her 40-year career as a professor of microbiology, Abigail A. Salyers, PhD, revolutionized how we think about the bacteria that live in the human intestinal tract, made major contributions on carbohydrate metabolism and the transfer of antibiotic resistance carried on mobile elements in humans and animals and provided advice and insights on bioterrorism, transgenic plant safety, antibiotic resistance in medicine and agriculture, and more.

The Department of Microbiology is hosting a special symposium in celebration of the life and work of Abigail A. Salyers.

For more information about the exciting lineup of speakers and scientific program, as well as meeting registration, accommodations, and donation opportunities, please visit the symposium website.

The registration deadline is Friday, October 17, 2014.

Salyers Memorial Symposium Website     
Posted June 24, 2014
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Kalsotra Awarded Nationally Competitive March of Dimes Research Grant

Assistant professor of biochemistry and medical biochemistry, Auinash Kalsotra, has been awarded the Basil O’Conner Starter Scholar Research Award from the March of Dimes. Created in 1973 and named for the first March of Dimes chairman and president, this program provides funding to young investigators to start their own research projects on topics related to the March of Dimes mission. The grant provides $150,000 over a two-year period for research on alternative splicing’s role in Myotonic Dystrophy, a multi-systemic disease that affects about 1 in 8000 people.

Alternative splicing is a key mechanism that produces precise assortment of proteins for each cell type. It is a highly regulated process, which when gone awry results in diseases like myotonic dystrophy type 1 (DM1). DM1 arises due to an unusual mutation where a small DNA segment of the mutated gene is repeated hundreds of times. When the mutated gene is copied into RNA, it gets trapped inside the nucleus and becomes toxic by disrupting function of muscleblind like (Mbnl) family of splicing regulatory factors. Mbnl proteins normally participate in regulation of developmental splicing transitions. Their inactivation in DM1 results in expression of embryonic splicing patterns, which is detrimental to the function of adult tissues.

While the role of Mbnl1 in DM1 skeletal and cardiac muscle pathology is clear, the effects of its loss of activity in the gastro-intestinal and other tissues are poorly understood. Dr. Kalsotra's project aims to characterize Mbnl1 function in the liver by identifying its RNA targets and determining the consequences of its loss on liver physiology and function. These studies will advance our understanding of Mbnl1 function in liver development and provide new insights into DM1 pathophysiology.

The mission of the March of Dimes is to promote healthy pregnancies and to support research that can lead to the prevention of birth defects. Dr. Kalsotra’s research will lead to our understanding of molecular mechanisms that may be responsible for the developmental defects observed in this debilitating disease. Dr. Kalsotra holds appointments in both the College of Medicine and the School of Molecular and Cellular Biology at the University of Illinois at Urbana-Champaign.

     
Posted February 19, 2014
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MicroRNA misregulation in muscular dystrophy

Assistant Professor of Biochemistry, Auinash Kalsotra, and colleagues have discovered the process by which myotonic dystrophy affects activity of the small bits of genetic material called microRNAs in the heart. Cardiovascular dysfunctions are the second leading cause of death in people with this particular type of muscular dystrophy. Their findings were published in the journal Cell Reports on January 9, 2014.

According to Dr. Kalsotra, myotonic dystrophy is a multi-systemic disease that affects about 1 in 8000 people. It occurs because of a change in a gene that is important for muscles. (Specifically, it is a trinucleotide repeat expansion in the dystrophia myotonica-protein kinase gene.) While most myotonic dystrophy research has focused on problems related to types of messenger RNAs produced from our genes by altered RNA splicing, this study demonstrates additional problems with expression of a class of regulatory RNAs known as microRNAs.

Dr. Kalsotra has appointments in both the College of Medicine and the School of Molecular and Cellular Biology at the University of Illinois at Urbana-Champaign.

Read the paper in Cell Reports     
Posted January 24, 2014
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Assistant Professor of MIP Sayee Anakk Publishes New Study in Cell Reports

Assistant Professor of Molecular and Integrative Physiology Sayeepriyadarshini Anakk published an article in the November 21, 2013, edition of Cell Reports entitled "Bile Acids Activate YAP to Promote Liver Carcinogenesis."

The article elucidates some of the ways elevated levels of bile acids cause liver cell carcinomas, including through the loss of the nuclear receptors FXR and SHP, as well as the activation of the Yes-associated Protein (YAP) of the Hippo pathway.

The MCB Communications Office also produced its first video abstract for the article.

Link to the paper and video abstract     
Posted November 22, 2013
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MCB Junior Receives ASM Undergraduate Research Fellowship

The American Society for Microbiology (ASM) has selected MCB Honors student Michaela Eickhoff as a 2013 award recipient of the ASM Undergraduate Research Fellowship. This fellowship is aimed at highly competitive students who wish to pursue graduate careers (Ph.D. or M.D./Ph.D.) in microbiology. Fellows have the opportunity to conduct full time summer research at their institution with an ASM mentor and present their research results at the 114th ASM General Meeting in Boston, MA if their abstract is accepted. Each fellow receives up to a $4,000 stipend, a two-year ASM student membership, and funding for travel expenses to the ASM Capstone Institute and 114th ASM General Meeting. Ms. Eickoff works in the lab of Professor of Microbiology James Slaugh.

     
Posted November 20, 2013
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MCB Undergrad and Staff Writer Wins Science Journalism Student Award

MCB senior and Communications Office writer Chelsey Coombs has won the Society of Neuroscience 2013 Science Journalism Student Award. The award includes a stipend and financial assistance attending Neuroscience 2013. Coombs is also a University of Illinois News Bureau Life Sciences Intern, a Researcher in Dr. Gene Robinson's Honey Bee Laboratory, and SPIN Fellow at the National Center for Supercomputing Applications.

     
Posted October 25, 2013
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Researcher in Newmark Laboratory Wins Bioart Contest

Bo Wang, a post-doctoral researcher, is one of twelve winners of the NIH's BioArt Contest. Wang works in the laboratory of Professor of Cell and Developmental Biology Phil Newmark.

Read a post about Wang's image on the NIH Director's Blog.     
Posted October 24, 2013
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Susan Martinis Named as a 2013 University Scholar

The Office of the Vice President of Academic Affairs recognized Professor and Head of Biochemistry Susan Martinis as one of six University Scholars at the Urbana-Champaign campus for 2013.

Martinis researches the interactions of RNA and proteins, specifically focusing on aminoacyl-tRNA synthetases. This family of enzymes accurately attaches an amino acid to its compatible tRNA molecule. A ribosome can then transfer the amino acid from this "charged" aminoacyl-tRNA molecule to a growing peptide chain. These enzymes are crucial in ensuring sequence fidelity between DNA sequences and the proteins they encode.

The University Scholars Program began in 1985 to identify "the most talented faculty members from many different disciplines" and "encourage continued professional growth and contributions to the University and the public it serves." University Scholars receive $10,000 for each of three years for career enhancement.

     
Posted September 12, 2013
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"Photosynthesis Research" Dedicates Article Series to Govindjee

The journal "Photosynthesis Research" announced the publication of a series of articles in honor of Emeritus Professor of Biochemistry Govindjee's contributions to photosynthesis research and education.

Govindjee has authored or co-authored over 400 publications about the details of photosynthesis and has served as a research collaborator, lecturer and editor. In the editorial announcing the special issues, Govindjee was called "the de facto Ambassador of Photosynthesis to the rest of the world."

Nearly 250 authors, representing 30 countries, contributed over 60 papers for these special issues, crafting their reviews to educate field novices and teachers of photosynthesis, as well as researchers looking for quick updates on the newest photosynthesis research.

Special issues on Photosynthesis Education honoring Govindjee Editorial     
Posted September 12, 2013
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College of Medicine Recognizes Byron Kemper, Abigail Salyers for Excellence

The College of Medicine at Illinois recognized Emeritus Professor of Molecular and Integrative Physiology Byron Kemper and Arends Professor Emerita of Microbiology Abigail A. Salyers for their excellence in research and teaching.

Kemper has published over 100 papers about cytochromes P450, a superfamily of enzymes that catalyze the oxidative metabolism of many compounds and play important roles as activators and inactivators of drugs and carcinogens. He currently studies the role of nuclear receptors in the regulation of liver metabolism with his wife, Associate Professor of Molecular and Integrative Physiology Jongsook Kim Kemper. Kemper has taught physiology, cell biology, and ethics courses in the School of Molecular and Cellular Biology and has also served as the Head of the Department of Molecular and Integrative Physiology.

Salyers has published over 150 papers about the normally occurring bacteria of the human intestinal tract, which can cause infection after surgery and have become antibiotic-resistant over time. She received the G. William Arends endowed appointment in 2004 for her research achievements. Salyers has served on multiple federal advisory panels and as the President of the American Society for Microbiology. She has also been recognized for her valuable instruction to students, being awarded the Golden Apple Award, as well as appearing on the List of Teachers Ranked as Excellent by Their Students.

Honoring Dr. Abigail A. Salyers, Arends Professor Emerita of Microbiology in the College of Medicine
Honoring Byron Kemper, Professor Emeritus of Pharmacology, Molecular and Integrative Physiology, and Cellular and Structural Biology     
Posted September 10, 2013
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Auinash Kalsotra Nominated for Searle Scholars Program

Congratulations to Auinash Kalsotra for his latest honor: a campus nomination for the prestigious Searle Scholars Program. Dr. Kalsotra is a member of the departments of Medical Biochemistry and Biochemistry in the College of Medicine and the School of Molecular and Cellular Biology, respectively. He recently received a Roy J. Carver Trust grant for his research on patterns in RNA splicing that determine the way liver cells naturally regenerate healthy cells across the life span.

Two scholars from the University of Illinois at Urbana-Champaign were nominated for this competitive award. The Searle Scholars Program generally selects 15 outstanding young scientists among a national pool of nominees from invited institutions. Grants are $300,000 for a three-year term. Final selections will be announced in April 2014.

Dr. Kalsotra’s research aims to shed light on possible interventions that could ultimately help people with chronic liver disease, such as hepatitis or liver cancer, to improve the body’s natural ability to regenerate healthy cells.

     
Posted August 23, 2013
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New MCB Web Site

On Wednesday, August 21 the MCB Web Site was completely replaced. Please report any concerns to gillespi@illinois.edu.

     
Posted August 21, 2013
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New MCB Faculty Interviews

New interviews with K V Prasanth, Auinash Kalsotra, Jim Slauch, Mary Schuler, Martha Gillette, Raven Huang, Claudio Grosman and Gary Olsen are available online.

Watch the new faculty interview videos on the ensemble server.
Many more MCB faculty videos are online on the MCB site.     
Posted August 20, 2013
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Assistant Professor Auinash Kalsotra Awarded Two-Year Roy J. Carver Trust Grant

Congratulations to Assistant Professor of Biochemistry Auinash Kalsotra, who was recently awarded a two-year grant to study the functional role of RNA processing, a cellular process that, among other roles, regulates liver regeneration. Dr. Kalsotra is a member of the Departments of Biochemistry and Medical Biochemistry, and will be teaching first-year medical students.

Dr. Kalsotra’s laboratory, in collaboration with Dr. Sayee Anakk, assistant professor of medical molecular and integrative physiology, has identified patterns in RNA splicing that determine the way liver cells naturally regenerate healthy cells across the life span. The Carver Trust grant will fund research to understand how splicing in diseased liver cells deviates from the typical patterns, specifically focusing on how alternative splicing functions in promoting cellular repair and regeneration.

Dr. Kalsotra’s research aims to shed light on possible interventions that could ultimately help people with chronic liver disease, such as hepatitis or liver cancer, to improve the body’s natural ability to regenerate healthy cells—a process that is impeded in a diseased organ.

The Roy J. Carver Charitable Trust supports advanced scientific research to improve human health. Applicants from the fields of medicine, engineering, and the natural sciences compete regionally for large, multiyear grants.

This funding will build on current work supported by the American Heart Association, which examines how changes in alternative splicing facilitate the growth of the heart after birth.

     
Posted August 03, 2013
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Ning Sun Receives Baxter Young Investigator Award

Biochemistry Ph.D. student Ning Sun (Huimin Zhao Lab) was selected to receive a Baxter Young Investigator Award.  Baxter Young Investigator Award Committee Member Judith L. Reinboldt says of the many nominations this year, that Sun's research "stood out as an example of innovative research," and is "not only challenging, but has potential application to critical care therapies and may lead to life sustaining therapies."


     
Posted August 02, 2013
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