Mark Nelson's research demonstrates the success of interdisciplinary approaches
From weakly electric fish to a robotic cockroach to a novel approach to using wireless networks for emergency response, Mark E. Nelson’s research career exemplifies the success of an interdisciplinary approach through his work in the Department of Molecular and Integrative Physiology and the Beckman Institute.
May 13, 2019
Researchers find protein that suppresses muscle repair in mice
Researchers report that a protein known to be important to protein synthesis also influences muscle regeneration and regrowth in an unexpected manner. The discovery, reported in the Journal of Clinical Investigation, could one day lead to new methods for treating disorders that result in muscle weakness and loss of muscle mass, the...
May 13, 2019
Professor William Brieher receives LAS Dean’s Award for Excellence in Undergraduate Teaching
Professor William Brieher has been selected by an awards committee to receive the LAS Dean’s Award for Excellence in Undergraduate Teaching, alongside four other professors at Illinois. This honor grants the recipients $1,000 to support their teaching and research, while a one-time increment of $2,000 will be added to...
April 24, 2019
Kuzminov lab: What causes thymineless death?
The latest paper by the Kuzminov lab investigates the mechanism of thymineless death, which is a common mode of action of anti-cancer and anti-bacterial drugs. The findings were published in a paper titled "Sources of thymidine and analogs fueling futile damage-repair cycles and ss-gap accumulation during thymine starvation in Escherichia coli" in DNA Repair.
April 22, 2019
Shapiro lab: Investigating breast cancer metastasis
The latest paper by the Shapiro lab looks at the effect of mutations in the estrogen receptor on the growth and spread of breast cancer cells. The findings were published in a paper titled "Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations" in Cancer Letters.
April 08, 2019
Ralph S. Wolfe, who helped discover new domain of life, dies at 97
Microbiologist Ralph Wolfe contributed to a study of microbes that led to the discovery of a third superkingdom, or domain, of life: the archaea. Wolfe, a professor emeritus of microbiology at the University of Illinois, died March 26 in Urbana. He was 97.
April 03, 2019
Mutations in noncoding genes could play big role in regulating cancer, study finds
Professor Kannanganattu Prasanth led a team that found that certain genes that don’t code for proteins could play an important regulatory role in breast cancer.
March 14, 2019
A new light on learning
School of Molecular and Cellular Biology creates an inspiring new space for instruction and advising
March 12, 2019
Govindjee: A pioneer in photosynthesis
A career spanning six decades, over 400 papers, 25 graduate students, and numerous awards surely means a relaxing retirement? Not quite. Govindjee, at 86 years, is still dissecting the mechanisms of photosynthesis. He also collaborates with researchers across the globe to improve crops for food and energy production.
February 19, 2019
Kuzminov lab: Reconciling a historical contradiction
The latest paper by the Kuzminov lab describes the development of a highly sensitive method to probe the nature of DNA replication in E. coli. The findings were published in a paper titled “Near-continuously synthesized leading strands in Escherichia coli are broken by ribonucleotide excision” in the Proceedings in the National Academy of Sciences.
February 05, 2019
Brooke lab: How does a viral infection ward off subsequent infections in host cells?
The latest paper by the Brooke lab investigates the mechanism through which an Influenza A-infected host cell can be rendered resistant to subsequent viral infections. The findings were published in a paper titled “Influenza A Virus Superinfection Potential Is Regulated by Viral Genomic Heterogeneity” in mBio.
January 18, 2019
Kai Zhang lab: Using light to dissect neuronal development
The Zhang lab recently published a paper in Cell Chemical Biology titled "Optogenetic delineation of receptor tyrosine kinase subcircuits in PC12 cell differentiation."
January 17, 2019
Researchers discover another role for cell protein
Discovery provides deeper insight into DNA and the fight against cancer
January 15, 2019
Dr. Hong Jin selected as an LAS 2019-2020 Helen Corley Petit Scholar
"It is my pleasure to inform you that Dr. Hong Jin, UIUC Biochemistry Assistant Professor, was selected as an LAS 2019-2020 Helen Corley Petit Scholar," said Dr. Emad Tajkhorshid, Interim Head Department of Biochemistry. "The scholarship is provided by an endowment for development of the scholarship and teaching...
December 21, 2018
MCB Magazine: Small but Mighty; Tiny Organisms that Make a Big Impact
Our fall issue of the MCB magazine focuses on the diverse ways in which microbes affect our health.
December 17, 2018
Anakk Lab: The consequences of losing a scaffold
The Anakk lab has investigated the metabolic repercussions of deleting the scaffolding protein IQGAP1. These findings were published in a paper entitled "Identification of IQ motif-containing GTPase Activating Protein 1 as a regulator of long-term ketosis" in JCI Insight.
December 12, 2018
Christian Lab: Effects of epilepsy on neural activity in mice fluctuate with reproductive cycle, study finds
Mice with epilepsy have altered patterns of neuron activity in the portion of the brain that controls the reproductive endocrine system, University of Illinois researchers report in a new study.
October 14, 2018
Kehl-Fie Lab: PhoPR plays important role in S. aureus virulence
In work published in Infection and Immunity, graduate student Jessica Kelliher, from the laboratory of Dr. Thomas Kehl-Fie, investigated how the superbug Staphylococcus aureus regulates the acquisition of phosphate.
October 03, 2018
K.V. Prasanth Lab: Uncovering a novel role of a lncRNA during cell proliferation
The Prasanth lab has recently published a paper in Nucleic Acids Research> titled “MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs.”
September 28, 2018
Study: Damaged liver cells undergo reprogramming to regenerate
In Greek mythology, Zeus punishes the trickster Prometheus by chaining him to a rock and sending an eagle to eat a portion of his liver every day, in perpetuity. It was the right organ to target – the liver has the ability to regenerate itself, though not overnight nor for eternity. New research...
September 27, 2018
Study: Kidney stones have distinct geological histories
Using a suite of techniques both common and new to geology and biology, researchers, from left, M.D./Ph.D. student Jessica Saw, geologist and microbiologist Bruce Fouke, microscopy expert and plant biologist Mayandi Sivaguru and their colleagues made new discoveries about how kidney stones repeatedly grow and dissolve as they form inside the kidney.
September 18, 2018
Tajkhorshid Lab: Battling antimicrobial resistance
Update: The article has been featured by an invited commentary in PNAS.
From the commentary by Jana Shen:
“In PNAS, Vermaas et al. report a computational study that combines a battery of state-of the-art modeling and simulation tools to shed new light on the perplexing drug–proton antiport mechanism of EmrE at the...
September 08, 2018
Painting the cell with different colors: A collaborative paper from the labs of Kai Zhang and Dipanjan Pan
The Zhang and Pan labs recently published a joint paper in Nanoscale titled “Carbon dots with induced surface oxidation permits imaging at single-particle level for intracellular studies.”
August 30, 2018
Researchers develop “cytological ruler” to build 3D map of human genome
This research has been featured on the NIH director's blog. It has been almost 20 years since the human genome was first sequenced, but researchers still know little about how the genome is folded up and organized within cells. In a new paper in the Journal of Cell Biology,...
August 28, 2018
Study: Abnormal expression and phosphoinositide regulation of KCNQ/Kv7 channels linked to severe form of genetic epilepsy
Molecular and integrative physiology professor Hee Jung Chung (left), postdoctoral fellow Eung Chang Kim (right), and their colleagues discovered that abnormal expression and phosphoinositide regulation of KCNQ/Kv7 potassium channels underlie neuronal hyperexcitability and injury in early-onset epileptic encephalopathy characterized by drug-resistant seizures and severe psychomotor...
August 25, 2018
Congratulations to Monica Chinea Diliz on receiving the Hispanic Scholarship Fund Outstanding Scholar Award!
Monica has been recognized as an Outstanding Scholar by the Hispanic Scholarship Fund and as a Chester and Nadine Houston graduate fellow.
July 26, 2018
College of LAS names alumni award winners from CDB and MICRO
The College of Liberal Arts & Sciences has announced the recipients of its 2018 annual alumni awards: Anne Carpenter, (PhD,'03 CSB) and Joanne Chory, (MS, '80 MICRO).
July 24, 2018
John Cronan Lab: Solving the process of lipoic acid assembly in humans
The Cronan lab recently published a paper in PNAS titled “Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes.”
July 24, 2018
RNA-Binding protein, Mov10, is key to both survival and brain function
A study led by Dr. Geena Skariah, a recent Neuroscience graduate of the Ceman lab in Cell and Developmental Biology, and current postdoctoral researcher at the University of Michigan, revealed the importance of the protein Mov10 (Moloney leukemia virus 10) in neurological development in animals. The findings were published in...
July 24, 2018
Engineering T cells to attack cancer
The Kranz lab and colleagues have recently publish a trio of papers that describe the engineering of receptors that can mediate specific and potent destruction of cancers by T cells.
July 24, 2018
Undergraduate Students: Instruction, Advising, Courses and Opportunities
Please visit the MCB Advising site for info.
July 24, 2018
Dr. Brenda Wilson honored with the Dr. Larine Y. Cowen Leadership in Diversity Award
Watch this video to learn more about Dr. Wilson’s leadership in diversity. The Celebration of Diversity program is an annual event that brings together campus and community leaders to affirm their collective support for an inclusive society and community. This event celebrates the achievements of faculty,...
July 24, 2018
Jongsook Kim Kemper Lab: Novel regulatory pathways in the liver for maintenance of metabolic homeostasis in mice
The Kemper lab has recently published two high-profile papers on metabolic regulation in the Journal of Clinical Investigation and Nature Communications.
July 23, 2018
July 23, 2018
Science Image by Rajashekar Iyer, Gillette Lab, featured by NSF
Part of the Art of Science program at the Carl R. Woese Institute for Genomic Biology at the University of Illinois (U of I), this delicate structure is a single brain cell (neuron) from a region of the brain called the hippocampus, which contributes to the formation and recall of memories....
July 23, 2018
K.V. Prasanth lab discovers cancer connections with MALAT1
Written by Doug Peterson Kannanganattu V. Prasanth was a graduate student in India a little over 20 years ago when he was told that no one was interested in long non-coding RNAs (lncRNAs). Some of the professors also lamented that there was little future for studying the function of the so-called “unimportant and...
July 22, 2018
Study: Protein found to be key component in irregularly excited brain cells
Research scientist Kwan Young Lee, left, molecular and integrative physiology professor Nien-Pei Tsai and their colleagues discovered that an overabundance of the tumor suppressor protein p53 in neurons can lead to impaired regulation of neuronal excitability in a mouse model of Fragile X syndrome.
July 17, 2018
Researchers discover a starring role for chaperone protein Hfq in gene regulation
A cell’s efforts to respond and adapt to its external environment rely on an elaborate yet coordinated set of molecular partnerships within. The more we learn about this complicated internal dance, the more we appreciate the flexibility of its roles. In a recent University of Illinois study, graduate student...
June 27, 2018