Illinois logo MCB The Department of Cellular and Developmental Biology
Claudio Grosman.

Welcome to Molecular and Integrative Physiology

In this post-genomic era, physiology is uniquely poised at the nexus between molecular function and whole animal integration with the goal of understanding how the functions of thousands of encoded proteins serve to bring about the highly coordinated behavior of cells and tissues underlying physiological functions in animals and how their dysfunction may lead to disease.  Research and graduate training in the Department of Molecular & Integrative Physiology is focused on understanding the regulation and function of gene products at multiple levels of biological organization, from molecules and macromolecular complexes to cells, tissues, and whole organisms. With the tools of molecular genetics and modern systems biology, physiologists are at the forefront of dramatic advances currently occurring in life and biomedical sciences. Advanced training in molecular and integrative physiology will provide the necessary foundation to prepare for a career in this exciting area of functional biology.

Claudio Grosman, Head


MIP News

In biology, it is generally believed that a protein’s sequence determines its structure, which in turn determines its function. However, in the case of membrane proteins, the reality is more complicated than this simple statement. “In recent years, the importance of a protein’s local environment has been increasingly recognized, but the molecular-level details have not been quite clear”, says Dr. Yuhang (“Steven”) Wang, co-author of a recent paper from the Grosman and Tajkhorshid labs published earlier this month in PNAS.
Scientists have developed new drug compounds that thwart the pro-cancer activity of FOXM1, a transcription factor that regulates the activity of dozens of genes. The new compounds suppress tumor growth in human cells and in mouse models of several types of human breast cancer.
See all MCB news...