Contact Information
3840 VMBSB
2001 S Lincoln Ave.
2001 S Lincoln Ave.
Research Areas
Associate Professor, Comparative Biosciences
Affiliate Professor, Molecular & Integrative Physiology
Research Interests
My laboratory is interested in understanding how lipid metabolism is regulated in physiology and how dysregulation of lipid metabolism contributes to diseases, including fatty liver disease, cardiovascular disease, obesity, diabetes and cancer.
Additional Campus Affiliations
Associate Professor, Comparative Biosciences
Associate Professor, Nutritional Sciences
Affiliate, Personalized Nutrition Initiative, Carl R. Woese Institute for Genomic Biology
Recent Publications
- Zhao Z, Lu W, Li C, Xu M, Wang B. Intestinal KLHL12 is dispensable for lipid absorption and chylomicron metabolism. American Journal of physiology. Endocrinology and Metabolism 329 (2), E233-E240
- Shi R, Lu W, Zhao Z, Wang B. Low-density lipoprotein regulates intestinal stem cell homeostasis via PPAR pathway. Journal of Lipid Research, 100826
- Sharma A, Zalejski J, Bendre SV, Kavrokova S, Hasdemir HS, Ozgulbas DG, Sun J, Pathmasiri KC, Shi R, Aloulou A, Berkley K, Delisle CF, Wang Y, Weisser E, Buweneka P, Pierre-Jacques D, Mukherjee S, Abbasi DA, Lee D, Wang B, Gevorgyan V, Cologna SM, Tajkhorshid E, Nelson ER, Cho W. Cholesterol-targeting Wnt-β-catenin signaling inhibitors for colorectal cancer. Nat Chem Biol. 2025 Apr 16. doi: 10.1038/s41589-025-01870-y. PMID: 40240631
- Tian, Y., Lu, W., Shi, R., McGuffee, R., Lee, R., Ford, D.A., Wang, B. Targeting phospholipid remodeling pathway improves insulin resistance in diabetic mouse models. The FASEB J. 2023, e23251
- Tian, Y., Jellinek, M.J., Mehta, K., Seok, S., Kuo, S., Lu, W., Shi, R., Lee, R., Lau, G.W., Kemper, K.J., Zhang, K., Ford, D.A., Wang, B. Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis. Hepatology, 2024 Apr 1;79(4):882-897.
- Tian, Y., Mehta, K., Jellinek, M.J., Sun, H., Lu, W., Shi, R., Ingram, K., Friedline, R.H., Kim, J.K., Kemper, K.J., Ford, D.A., Zhang, K., Wang, B. Hepatic phospholipid remodeling modulates insulin sensitivity and systemic metabolism. Advanced Science, DOI: 10.1002/advs.202300416
- Shi, R., Lu, W., Tian, Y., Wang, B. Intestinal SEC16B modulates obesity by regulating chylomicron metabolism. Molecular Metabolism, 2023; 70:101693