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Edward J Roy

Profile picture for Edward J Roy

Contact Information

407 S. Goodwin Avenue
Urbana, IL 61801
Affiliate Professor, Molecular & Integrative Physiology
Emeritus Professor of Pathology and Neuroscience

Research Interests

Research Topics

Molecular Immunology

Research Description


We are committed to developing immunotherapies for brain tumors that are effective and selective.  We use mice as experimental subjects because much is know about their immune system, and the murine system closely parallels the human immune system.  When properly activated, the immune system has the characteristics of an ideal therapy: potent, precise killing of altered cells.  But there is much to be learned about how to activate, direct, and control the immune response, particularly against tumors within the brain.  We focus mostly on T cell mediated immune responses, and work in close collaboration with the laboratory of David Kranz, a T cell biochemist.


B.A. 1970 Brown University
Ph.D. 1976 University of Massachusetts
Postdoc. 1976-1979 The Rockefeller University

Additional Campus Affiliations

Affiliate, Carl R. Woese Institute for Genomic Biology
Department Affiliate, Molecular and Integrative Physiology

Recent Publications

Lichtor, T., Tang, B., & Roy, E. J. (2023). Cytokine Gene Vaccine Therapy for Treatment of a Brain Tumor. Brain Sciences, 13(11).

Ranoa, D. R. E., Sharma, P., Schane, C. P., Lewis, A. N., Valdez, E., Marada, V. V. V. R., Hager, M. V., Montgomery, W., Wolf, S. P., Schreiber, K., Schreiber, H., Bailey, K., Fan, T. M., Hergenrother, P. J., Roy, E. J., & Kranz, D. M. (2023). Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. Journal for ImmunoTherapy of Cancer, 11(5), Article e006509.

Boudreau, M. W., Duraki, D., Wang, L., Mao, C., Kim, J. E., Henn, M. A., Tang, B., Fanning, S. W., Kiefer, J., Tarasow, T. M., Bruckheimer, E. M., Moreno, R., Mousses, S., Greene, G. L., Roy, E. J., Park, B. H., Fan, T. M., Nelson, E. R., Hergenrother, P. J., & Shapiro, D. J. (2021). A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Science Translational Medicine, 13(603), Article eabf1383.

Tang, B., Guo, Z. S., Bartlett, D. L., Yan, D. Z., Schane, C. P., Thomas, D. L., Liu, J., McFadden, G., Shisler, J. L., Roy, E. J., & Roy, E. J. (2020). Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma. Clinical Cancer Research, 26(9), 2216-2230.

Tang, B., Guo, Z. S., Bartlett, D. L., Liu, J., McFadden, G., Shisler, J. L., & Roy, E. J. (2019). A Cautionary Note on the Selectivity of Oncolytic Poxviruses. Oncolytic virotherapy, 8, 3-8.

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