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Edward J Roy

Profile picture for Edward J Roy

Contact Information

407 S. Goodwin Avenue
Urbana, IL 61801
Affiliate Professor, Molecular & Integrative Physiology
Professor of Pathology and Neuroscience

Research Interests

Research Topics

Molecular Immunology

Research Description

Immunotherapy

We are committed to developing immunotherapies for brain tumors that are effective and selective.  We use mice as experimental subjects because much is know about their immune system, and the murine system closely parallels the human immune system.  When properly activated, the immune system has the characteristics of an ideal therapy: potent, precise killing of altered cells.  But there is much to be learned about how to activate, direct, and control the immune response, particularly against tumors within the brain.  We focus mostly on T cell mediated immune responses, and work in close collaboration with the laboratory of David Kranz, a T cell biochemist.

Education

B.A. 1970 Brown University
Ph.D. 1976 University of Massachusetts
Postdoc. 1976-1979 The Rockefeller University

Additional Campus Affiliations

Professor Emeritus, Molecular and Integrative Physiology
Affiliate, Carl R. Woese Institute for Genomic Biology

Recent Publications

Boudreau, M. W., Duraki, D., Wang, L., Mao, C., Kim, J. E., Henn, M. A., Tang, B., Fanning, S. W., Kiefer, J., Tarasow, T. M., Bruckheimer, E. M., Moreno, R., Mousses, S., Greene, G. L., Roy, E. J., Park, B. H., Fan, T. M., Nelson, E. R., Hergenrother, P. J., & Shapiro, D. J. (2021). A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice. Science Translational Medicine, 13(603), [eabf1383]. https://doi.org/10.1126/scitranslmed.abf1383

Tang, B., Guo, Z. S., Bartlett, D. L., Yan, D. Z., Schane, C. P., Thomas, D. L., Liu, J., McFadden, G., Shisler, J. L., Roy, E. J., & Roy, E. J. (2020). Synergistic Combination of Oncolytic Virotherapy and Immunotherapy for Glioma. Clinical Cancer Research, 26(9), 2216-2230. https://doi.org/10.1158/1078-0432.CCR-18-3626

Tang, B., Guo, Z. S., Bartlett, D. L., Liu, J., McFadden, G., Shisler, J. L., & Roy, E. J. (2019). A Cautionary Note on the Selectivity of Oncolytic Poxviruses. Oncolytic virotherapy, 8, 3-8. https://doi.org/10.2147/OV.S189832

Biswas, S., Smith, G. L., Roy, E. J., Ward, B., & Shisler, J. L. (2018). A comparison of the effect of molluscum contagiosum virus MC159 and MC160 proteins on vaccinia virus virulence in intranasal and intradermal infection routes. Journal of General Virology, 99(2), 246-252. [001006]. https://doi.org/10.1099/jgv.0.001006

Kowalsky, S. J., Liu, Z., Feist, M., Berkey, S. E., Ma, C., Ravindranathan, R., Dai, E., Roy, E. J., Guo, Z. S., & Bartlett, D. L. (2018). Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade. Molecular Therapy, 26(10), 2476-2486. https://doi.org/10.1016/j.ymthe.2018.07.013

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