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Isaac Cann

Profile picture for Isaac Cann

Contact Information

3408 Institute for Genomic Biology
1206 West Gregory Drive
MC-195
Urbana, IL 61801

Professor of Animal Sciences
Affiliate Professor, Microbiology

Research Interests

Research Topics

Archaea, Biofuels, Enzymology, Genomics, Host-Pathogen Interactions, Molecular Evolution, Protein Structure, Protein-Nucleic Acid Interactions

Research Description

Molecular biology and biochemistry of archaeal DNA replication; host-microbiome interactions; enzymes of plant cell wall hydrolysis

The research of the Cann lab focuses on three areas:

  • DNA replication in the archaeal domain of life
  • Host-microbiome interactions and their effects on health and disease
  • Enzymes of importance to biofuel production

Isaac Cann is a member of two themes at the Carl R. Woese Institute for Genomic Biology (IGB), and his research is carried out at the space shared by his affiliated themes [Microbiome Metabolic Engineering (MME) and Biocomplexity (BCXT)] with others at the IGB.

Education

B.Sc (Hons) Animal Sciences, University of Ghana 1986
M.S. (Rumen Microbiology), Mie University, Japan, 1991
Ph.D. (Rumen Microbiology), Mie University, Japan, 1994
Postdoctoral (Anaerobic Microbiology), Department of Animal Sciences, University of Illinois, 1994-1997

Awards and Honors

National Science Foundation CAREER Award 2003
Fellow, Center for Advanced Study 2005
Excellence in Guiding Undergraduate Research Award (UIUC) 2012
Paul A. Funk Award, College of ACES 2014

Additional Campus Affiliations

Professor, Animal Sciences
Professor, Nutritional Sciences
Professor, Carl R. Woese Institute for Genomic Biology
Affiliate, Microbiology

Recent Publications

Abdel-Hamid, A. M., D'Alessandro-Gabazza, C. N., Yasuma, T., Walden, K. K. O., Fields, C. J., Gabazza, E. C., & Cann, I. (2022). Complete Genome Sequences of Three Staphylococcus haemolyticus Strains Isolated from the Lung of a TGFb1 Transgenic Mouse with Lung Fibrosis. Microbiology Resource Announcements, 11(4). https://doi.org/10.1128/mra.01176-21

Cerqueira, F. M., Photenhauer, A. L., Doden, H. L., Brown, A. N., Abdel-Hamid, A. M., Moraïs, S., Bayer, E. A., Wawrzak, Z., Cann, I., Ridlon, J. M., Hopkins, J. B., & Koropatkin, N. M. (2022). Sas20 is a highly flexible starch-binding protein in the Ruminococcus bromii cell-surface amylosome. Journal of Biological Chemistry, 298(5), [101896]. https://doi.org/10.1016/j.jbc.2022.101896

Chiu, K. K., Bashir, S. T., Abdel-Hamid, A. M., Clark, L. V., Laws, M. J., Cann, I., Nowak, R. A., & Flaws, J. A. (2022). Isolation of DiNP-Degrading Microbes from the Mouse Colon and the Influence DiNP Exposure Has on the Microbiota, Intestinal Integrity, and Immune Status of the Colon. Toxics, 10(2), [75]. https://doi.org/10.3390/toxics10020075

D’Alessandro-Gabazza, C. N., Yasuma, T., Kobayashi, T., Toda, M., Abdel-Hamid, A. M., Fujimoto, H., Hataji, O., Nakahara, H., Takeshita, A., Nishihama, K., Okano, T., Saiki, H., Okano, Y., Tomaru, A., Fridman D’Alessandro, V., Shiraishi, M., Mizoguchi, A., Ono, R., Ohtsuka, J., ... Gabazza, E. C. (2022). Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis. Nature communications, 13(1), [1558]. https://doi.org/10.1038/s41467-022-29064-3

Yi, Z., Su, X., Asangba, A. E., Abdel-Hamid, A. M., Chakraborty, S., Dodd, D., Stroot, P. G., Mackie, R. I., & Cann, I. (2022). Xylan Deconstruction by Thermophilic Thermoanaerobacterium bryantii Hemicellulases Is Stimulated by Two Oxidoreductases. Catalysts, 12(2), [182]. https://doi.org/10.3390/catal12020182

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