The Journal of Molecular Biology covers the following research areas:

• Biomolecular interactions, signaling networks, systems biology 
• Cell cycle, cell growth, cell differentiation 
• Cell death, autophagy 
• Cell signaling and regulation 
• Chemical biology 
• Computational biology, in combination with experimental studies 
• DNA replication, repair, and recombination 
• Development, regenerative biology, mechanistic and functional studies of stem cells 
• Epigenetics, chromatin structure and function 
• Gene expression 
• Receptors, channels, and transporters 
• Membrane processes 
• Cell surface proteins and cell adhesion 
• Methodological advances, both experimental and theoretical, including databases 
• Microbiology, virology, and interactions with the host or environment 
• Microbiota mechanistic and functional studies 
• Nuclear organization 
• Post-translational modifications, proteomics 
• Processing and function of biologically important macromolecules and complexes 
• Molecular basis of disease 
• RNA processing, structure and functions of non-coding RNAs, transcription 
• Sorting, spatiotemporal organization, trafficking 
• Structural biology 
• Synthetic biology 
• Translation, protein folding, chaperones, protein degradation and quality control