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Beth M. Stadtmueller

Assistant Professor of Biochemistry

Research Interests

Research Topics

Host-Pathogen Interactions, Molecular Immunology, Protein Dynamics, Protein Structure, Virology

Disease Research Interests

Infectious Diseases

Research Description

The Stadtmueller Lab aims to broaden understanding of immune system proteins, their interactions with microbes and the functional outcomes of those interactions. Specifically, the Stadtmueller Lab investigates the assembly, structures and functions of mucosal antibodies in order to understand how these remarkable complexes protect vertebrates from external factors (e.g. pathogens) and how they can be engineered to treat disease.  To accomplish this the lab targets data detailing the structures and biophysical mechanisms of mucosal antibodies from different species as well as mucosal antibody interactions with bacterial and viral antigens and receptors. Common approaches used in the lab include but are not limited to antibody engineering, cryoelectron microscopy, X-ray crystallography, surface plasmon resonance and fluorescence microscopy. Together, Stadtmueller lab projects are expanding our understanding of host-microbe co-evolution, antibody structure-function relationships and antibody therapeutic potential.  Please visit our webpage for more information. 


B.S. 2003 University of Wisconsin, Madison
Ph.D. 2010 University of Utah
Postdoc. 2011-2018 California Institute of Technology

Highlighted Publications

Representative Publications

Kumar Bharathkar, S.*, Parker, B. W.*, Malyutin, A. G., Haloi, N., Huey-Tubman, E. K., Tajkhorshid, E., Stadtmueller, B. M. (2020). "The structures of secretory and dimeric immunoglobulin A." Elife 9.

Stadtmueller B.M. , Bridges M.D., Dam K-M., Lerch M.T., Huey-Tubman K.E., Hubbell W.L., Bjorkman P.J. (2018) DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions. Immunity. 2018 Jul 26. [Epub ahead of print]

Stadtmueller, B.M. , Yang, Z., Huey-Tubman, K.E., Roberts-Mataric, H., Hubbell, W.L., and Bjorkman, P.J. (2016). Biophysical and biochemical characterization of avian secretory component provides structural insights into the evolution of the polymeric Ig receptor. J Immunol. 197(4): 1408-1414.

Featured “In this Issue:”

Stadtmueller, B.M. , Huey-Tubman, K.E., Lopez, C.J., Yang, Z., Hubbell, W.L., and Bjorkman, P.J. (2016). The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins. eLife 5. Featured in Caltech News:…

Stadtmueller, B.M.* , Kish-Trier E.*, Ferrell K., Robinson H., Myszka D.G., Formosa, T. Hill, C.P. (2012) Crystal structure of the Pba1/2-proteasome complex and implications for HbYX-dependent proteasome interactions. J Biol Chem 287(44):37371-82.

Stadtmueller, B.M. and Hill, C.P. (2011) “Proteasome Activators.” Mol Cell 41(1): 8-19.

Stadtmueller, B. M. , Ferrell K., Whitby F.G., Heroux A., Robinson H., Myszka D.G., Hill C.P. (2010) Structural models for interactions between the 20S proteasome and its PAN/19S activators. J Biol Chem 285(1): 13-7.

Recent Publications

Diefenbacher, M., Tan, T. J. C., Bauer, D. L. V., Stadtmueller, B. M., Wu, N. C., & Brooke, C. B. (2022). Interactions between Influenza A Virus Nucleoprotein and Gene Segment Untranslated Regions Facilitate Selective Modulation of Viral Gene Expression. Journal of virology, 96(10).

Diard, M., Bakkeren, E., Lentsch, V., Rocker, A., Bekele, N. A., Hoces, D., Aslani, S., Arnoldini, M., Böhi, F., Schumann-Moor, K., Adamcik, J., Piccoli, L., Lanzavecchia, A., Stadtmueller, B. M., Donohue, N., van der Woude, M. W., Hockenberry, A., Viollier, P. H., Falquet, L., ... Slack, E. (2021). A rationally designed oral vaccine induces immunoglobulin A in the murine gut that directs the evolution of attenuated Salmonella variants. Nature Microbiology, 6(7), 830-841.

Tan, T. J. C., Yuan, M., Kuzelka, K., Padron, G. C., Beal, J. R., Chen, X., Wang, Y., Rivera-Cardona, J., Zhu, X., Stadtmueller, B. M., Brooke, C. B., Wilson, I. A., & Wu, N. C. (2021). Sequence signatures of two public antibody clonotypes that bind SARS-CoV-2 receptor binding domain. Nature Communications, 12(1), [3815].,

Bharathkar, S. K., Parker, B. W., Malyutin, A. G., Haloi, N., Huey-Tubman, K. E., Tajkhorshid, E., & Stadtmueller, B. M. (2020). The structures of secretory and dimeric immunoglobulin a. eLife, 9, 1-29. [e56098].

Stadtmueller, B. M., Bridges, M. D., Dam, K. M., Lerch, M. T., Huey-Tubman, K. E., Hubbell, W. L., & Bjorkman, P. J. (2018). DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions. Immunity, 49(2), 235-246.e4.

View all publications on Illinois Experts

In the news

  • Four faculty at the University of Illinois Urbana-Champaign, plus a collaborator in Colorado, have been awarded $9.5 million over three years by the Howard Hughes Medical Institute. The team is one of 13 selected by the institute as part of its $100 million Emerging Pathogens Initiative.
  • Professor Stadtmueller was one of ten new faculty hires made in the School of Molecular and Cellular Biology in the last three years. Stadtmueller is an assistant professor of biochemistry, assistant professor of Biomedical and Translational Sciences with the Carle Illinois College of Medicine, and...
  • It has been over 60 years since scientists first identified the molecule that we know today as immunoglobulin (Ig) A. IgA is the predominant class of antibody found in human mucus where it is known as secretory (S) IgA. SIgA functions to bind microbes in extracellular regions such as the gut and...