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Kwan Young Lee

Senior Research Scientist (PI: Dr. Nien-Pei Tsai)

Additional Campus Affiliations

Senior Research Scientist, Molecular and Integrative Physiology

Recent Publications

Kumar, V., Lee, K. Y., Acharya, A., Babik, M. S., Christian-Hinman, C. A., Rhodes, J. S., & Tsai, N. P. (2024). mGluR7 allosteric modulator AMN082 corrects protein synthesis and pathological phenotypes in FXS. EMBO Molecular Medicine, 16(3), 506-522. https://doi.org/10.1038/s44321-024-00038-w

Yook, Y., Lee, K. Y., Kim, E., Lizarazo, S., Yu, X., & Tsai, N. P. (2024). Hyperfunction of post-synaptic density protein 95 promotes seizure response in early-stage aβ pathology. EMBO Reports, 25(3), 1233-1255. https://doi.org/10.1038/s44319-024-00090-0

Lee, K. Y., Wang, H., Yook, Y., Rhodes, J. S., Christian-Hinman, C. A., & Tsai, N. P. (2023). Tumor suppressor p53 modulates activity-dependent synapse strengthening, autism-like behavior and hippocampus-dependent learning. Molecular Psychiatry, 28(9), 3782-3794. https://doi.org/10.1038/s41380-023-02268-9

Lee, K. Y., Zhu, J., Cutia, C. A., Christian‐Hinman, C. A., Rhodes, J. S., & Tsai, NP. (2021). Infantile spasms‐linked Nedd4‐2 mediates hippocampal plasticity and learning via cofilin signaling. EMBO Reports, 22(10), Article e52645. https://doi.org/10.15252/embr.202152645

Liu, D. C., Lee, K. Y., Lizarazo, S., Cook, J. K., & Tsai, N. P. (2021). ER stress-induced modulation of neural activity and seizure susceptibility is impaired in a fragile X syndrome mouse model. Neurobiology of Disease, 158, Article 105450. https://doi.org/10.1016/j.nbd.2021.105450

View all publications on Illinois Experts

In the news

  • University of Illinois researchers have established the protein p53 as critical for regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice, illuminating the relationship between the protein-coding gene TP53 and neurodevelopmental and psychiatric disorders...
  • Researchers report that infantile spasms, a rare but serious seizure disorder in babies, appear to be the result of a molecular pathway gone awry. In their study of a mouse model of the disorder, the researchers discovered that genetic mutations associated with the disease impair a pathway that is...
  • Research scientist Kwan Young Lee, molecular and integrative physiology professor Nien-Pei Tsai, and their colleagues discovered that an overabundance of the tumor suppressor protein p53 in neurons can lead to impaired regulation of neuronal excitability in a mouse model of Fragile X syndrome.