Research Interests
Professor Boppart's research focuses on exploring the molecular and cellular mechanisms responsible for skeletal muscle growth post-exercise. This information is then used to develop novel cell- and pharmacological-based interventions to prevent or treat loss of muscle mass after disuse, particularly in vulnerable populations (aging). We have a specific interest in developing stem cell, pericyte, and extracellular vesicle (EV)-based therapies.
Additional Campus Affiliations
External Links
Recent Publications
Connolly, M. G., Fliflet, A. M., Ravi, P., Rosu, D. I., Boppart, M. D., & Rhodes, J. S. (2025). Exercise-induced plasma-derived extracellular vesicles increase adult hippocampal neurogenesis. Brain Research, 1869, Article 150003. https://doi.org/10.1016/j.brainres.2025.150003
Tan, Y., Kao, W. C., Boppart, M., & Sweedler, J. V. (2025). Plasma-Derived Extracellular Vesicle Proteomics. Journal of Proteome Research, 24(9), 4309-4321. https://doi.org/10.1021/acs.jproteome.5c00316
Gupta, A. D., Park, J., Sorrells, J. E., Kim, H., Krawczynska, N., Pradeep, D., Wang, Y., Gamage, H. E. V., Nelczyk, A. T., Boppart, S. A., Boppart, M. D., & Nelson, E. R. (2024). 27-Hydroxycholesterol Enhances Secretion of Extracellular Vesicles by ROS-Induced Dysregulation of Lysosomes. Endocrinology (United States), 165(11), Article bqae127. https://doi.org/10.1210/endocr/bqae127
MISEV Consortium (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2), Article e12404. https://doi.org/10.1002/jev2.12404
Mavropalias, G., Boppart, M., Usher, K. M., Grounds, M. D., Nosaka, K., & Blazevich, A. J. (2023). Exercise builds the scaffold of life: muscle extracellular matrix biomarker responses to physical activity, inactivity, and aging. Biological Reviews, 98(2), 481-519. https://doi.org/10.1111/brv.12916