Research Interests
Professor Boppart's research focuses on exploring the molecular and cellular mechanisms responsible for skeletal muscle growth post-exercise. This information is then used to develop novel cell- and pharmacological-based interventions to prevent or treat loss of muscle mass after disuse, particularly in vulnerable populations (aging). We have a specific interest in developing stem cell, pericyte, and extracellular vesicle (EV)-based therapies.
Additional Campus Affiliations
External Links
Recent Publications
Gupta, A. D., Park, J., Sorrells, J. E., Kim, H., Krawczynska, N., Pradeep, D., Wang, Y., Gamage, H. E. V., Nelczyk, A. T., Boppart, S. A., Boppart, M. D., & Nelson, E. R. (2024). 27-Hydroxycholesterol Enhances Secretion of Extracellular Vesicles by ROS-Induced Dysregulation of Lysosomes. Endocrinology (United States), 165(11), Article bqae127. https://doi.org/10.1210/endocr/bqae127
MISEV Consortium (2024). Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. Journal of Extracellular Vesicles, 13(2), Article e12404. https://doi.org/10.1002/jev2.12404
Mavropalias, G., Boppart, M., Usher, K. M., Grounds, M. D., Nosaka, K., & Blazevich, A. J. (2023). Exercise builds the scaffold of life: muscle extracellular matrix biomarker responses to physical activity, inactivity, and aging. Biological Reviews, 98(2), 481-519. https://doi.org/10.1111/brv.12916
Paulussen, K. JM., Barnes, T. M., Askow, A. T., Salvador, A. F., McKenna, C. F., Scaroni, S. E., Fliflet, A., Ulanov, A. V., Li, Z., West, D. WD., Bauer, L. L., Paluska, S. A., Dilger, R. N., Moore, D. R., Boppart, M. D., & Burd, N. A. (2023). Underpinning the Food Matrix Regulation of Postexercise Myofibrillar Protein Synthesis by Comparing Salmon Ingestion With the Sum of Its Isolated Nutrients in Healthy Young Adults. Journal of Nutrition, 153(5), 1359-1372. https://doi.org/10.1016/j.tjnut.2023.02.037
Roberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., Libardi, C. A., Ugrinowitsch, C., Booth, F. W., & Esser, K. A. (2023). Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions. Physiological Reviews, 103(4), 2679-2757. https://doi.org/10.1152/physrev.00039.2022