Research Interests
Professor Boppart's research focuses on exploring the molecular and cellular mechanisms responsible for skeletal muscle growth post-exercise. This information is then used to develop novel cell- and pharmacological-based interventions to prevent or treat loss of muscle mass after disuse, particularly in vulnerable populations (aging). We have a specific interest in developing stem cell, pericyte, and extracellular vesicle (EV)-based therapies.
Additional Campus Affiliations
External Links
Recent Publications
Fliflet, A. M., Spradlin, R. A., Tan, Y., Nishitha Vijayan, A., Choi, S. J., Kao, W. C., Aksamitiene, E., Nelappana, M., Ding, S., Huang, K. Y., Joshi, A., Kambar, N., Bludgen, T., Meehan, M., Boss, J. L., Knipp, M., Fan, H., Leal, C., Sunde, R. A., ... Boppart, M. D. (2026). Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)-Enriched Extracellular Vesicles That Promote Angiogenesis. FASEB Journal, 40(12), Article e72052. https://doi.org/10.1096/fj.202505096RR
Fliflet, A. M., Tan, Y., Barnes, T. M., Vijayan, A. N., Choi, S. J., Deutz, M. T., Zupancic, Z., Miller, B. F., Burd, N. A., Sweedler, J. V., & Boppart, M. D. (2026). Human plasma extracellular vesicles as an exercise mimetic to preserve skeletal muscle plasticity during disuse. npj Microgravity. https://doi.org/10.1038/s41526-026-00582-4
Krawczynska, N., Wang, Y., Lim, K., Das Gupta, A., Molino, R. J. E. J., Lenczowski, A., Abughazaleh, M., Bendre, S. V., Fei, Y., Kim, H., Kockaya, L. I., Schane, C. P., Pradeep, D., Rodriguez-Casiano, D., Hernandez, A. G., Drnevich, J., Chan, J., Dobrucki, L. W., Boppart, M. D., ... Nelson, E. R. (2026). Neutrophils exposed to a cholesterol metabolite secrete extracellular vesicles that promote epithelial-mesenchymal transition and stemness in breast cancer cells. Cancer Letters, 636, Article 218105. https://doi.org/10.1016/j.canlet.2025.218105
Connolly, M. G., Fliflet, A. M., Ravi, P., Rosu, D. I., Boppart, M. D., & Rhodes, J. S. (2025). Exercise-induced plasma-derived extracellular vesicles increase adult hippocampal neurogenesis. Brain Research, 1869, Article 150003. https://doi.org/10.1016/j.brainres.2025.150003
Tan, Y., Kao, W. C., Boppart, M., & Sweedler, J. V. (2025). Plasma-Derived Extracellular Vesicle Proteomics. Journal of Proteome Research, 24(9), 4309-4321. https://doi.org/10.1021/acs.jproteome.5c00316