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Contact Information

321 Roger Adams Laboratory
600 South Mathews Avenue
Urbana, IL 61801
Professor of Biochemistry
Chemical Biology and Cancer Drug Discovery Laboratory
Phil and Ann Sharp Scholar in Cancer Drug Discovery

Additional Campus Affiliations

Recent Publications

Landgraf, A. D., Brenner, R., Ghozayel, M. K., Bum-Erdene, K., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2025). Small-Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation. ChemMedChem, 20(12), Article e202400624. https://doi.org/10.1002/cmdc.202400624

Yeh, I. J., Bum-Erdene, K., Ghozayel, M. K., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2025). Small-Molecule Covalent Stabilization and Inhibition of the TEAD·YAP1 Transcription Factor in Cancer Cells. ACS chemical biology, 20(9), 2142-2158. https://doi.org/10.1021/acschembio.5c00283

Brenner, R. J., Landgraf, A. D., Bum-Erdene, K., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2023). Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling. Biochemistry, 62(22), 3206-3213. https://doi.org/10.1021/acs.biochem.3c00378

Bum-Erdene, K., Ghozayel, M. K., Zhang, M. J., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2023). Chloroacetamide fragment library screening identifies new scaffolds for covalent inhibition of the TEAD·YAP1 interaction. RSC Medicinal Chemistry, 14(9), 1803-1816. https://doi.org/10.1039/d3md00264k

Bum-Erdene, K., Yeh, I. J., Gonzalez-Gutierrez, G., Ghozayel, M. K., Pollok, K., & Meroueh, S. O. (2023). Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists. Journal of Medicinal Chemistry, 66(1), 266-284. https://doi.org/10.1021/acs.jmedchem.2c01189

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