According to the journal's website:

IEEE Transactions on Medical Imaging (T-MI) encourages the submission of manuscripts on imaging of body structure, morphology and function, including cell and molecular imaging and all forms of microscopy. The journal publishes original contributions on medical imaging achieved by modalities including ultrasound, x-rays, magnetic resonance, radionuclides, microwaves, and optical methods. Contributions describing novel acquisition techniques, medical image processing and analysis, visualization and performance, pattern recognition, machine learning, and related methods are encouraged. Studies involving highly technical perspectives are most welcome.

The focus of the journal is on unifying the sciences of medicine, biology, and imaging. It emphasizes the common ground where instrumentation, hardware, software, mathematics, physics, biology, and medicine interact through new analysis methods. Strong application papers that describe novel methods are particularly encouraged. Papers describing important applications based on medically adopted and/or established methods without significant innovation in methodology will be directed to other journals.