Image
Researchers uncover the molecular basis of mitochondrial dysfunction in myotonic dystrophy type 1
Myotonic Dystrophy type 1, also known as DM1, is a genetic disorder that causes progressive muscle weakness, delayed muscle relaxation, and cardiac issues that can often be life-threatening. It is the most common cause of adult-onset muscular dystrophy and affects roughly 1 in 2,000 individuals...
Image
In new research, Van Bortle Lab untangles a noncoding RNA-based mechanism of cancer progression
Researchers from the University of Illinois Urbana-Champaign are piecing together how cancer-emergent non-coding RNAs, or ncRNAs, contribute to disease-related cell phenotypes. The Van Bortle lab has focused extensively on RNA polymerase III (Pol III) —...
Image
Researchers aim to disrupt breast cancer line of communication and prevent spread
University of Illinois researcher Erik Nelson and members of his lab have made an important discovery about the relationship between cholesterol and breast cancer progression with crucial implications for breast cancer therapeutics....
Image
A cellular protein, FGD3, boosts breast cancer chemotherapy, immunotherapy
A naturally occurring protein that tends to be expressed at higher levels in breast cancer cells boosts the effectiveness of some anticancer agents, including doxorubicin, one of the most widely used chemotherapies, and a preclinical drug known as ErSO, researchers report. The protein, FGD3,...
Image
Scientists link neuronal hyperactivity and broader tuning with altered sound processing
In a study that combines behavioral tests, computer models and electrophysiological recordings of neuron activity, researchers have found that hyperactivity of neurons in the auditory cortex and the reaction of these neurons to an unusually broad range of frequencies contribute to distorted...
Image
Illinois-led initiative will build precision phage platform for promoting health
University of Illinois Urbana-Champaign scientists, including microbiology professor Asma Hatoum-Aslan, will partner with investigators from several industrial and academic institutions on a five-year, up to $28M...
Image
Long-term alcohol use suspends liver cells in limbo, preventing regeneration
Excessive alcohol consumption can disrupt the liver’s unique regenerative abilities by trapping cells in limbo between their functional and regenerative states, even after a patient stops drinking, researchers at University of Illinois Urbana-Champaign and collaborators at Duke University and the...
Image
Microbiologists uncover novel proteins essential for maintaining magnesium homeostasis in Salmonella
In a newly published research, scientists from the School of Molecular & Cellular Biology have reported the discovery of novel proteins that keep Salmonella’s magnesium levels in balance.Yumi Iwadate, postdoctoral research...
Image
High-volume antibody testing platform could accelerate disease research and treatment development
Antibodies are the critical targeting agents of the immune system and the crux of immune therapy and vaccine development, but studying them is slow, expensive and labor-intensive. Now, researchers at the University of Illinois Urbana-Champaign have developed a new high-volume method that can...
Image
Map-making neurons change even in familiar settings, study finds
Neurobiologists at Northwestern University and the University of Illinois Urbana-Champaign, including Jason Climer in the School of Molecular & Cellular Biology, found the brain’s internal GPS changes each time mice navigate a...