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The Cancer Center at Illinois brings together cancer biologists, clinicians, engineers, and other specialists to accelerate advances in disease detection, prevention, therapy, and improve quality of life for patients.
Cholesterol metabolite causes immune system to attack T cells instead of breast cancer, study finds
In breast cancer tumors, a molecule produced when the body breaks down cholesterol hijacks the myeloid immune cells that normally arm T cells to fight cancer, a new study in mice found. Instead, the hijacked myeloid cells disarm the T cells and even tell them to self-destruct.
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Engineered immune cells recognize, attack human and mouse solid-tumor cancer cells
A method known as CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia. It modifies a patient’s own T-cells by adding a piece of an antibody that recognizes unique features on the surface of cancer cells. In a new study, researchers report that they...
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MIP Professor Benita Katzenellenbogen named Senior Advisor for the Cancer Center at Illinois
Benita S. Katzenellenbogen, Professor of Molecular and Integrative Physiology at the University of Illinois at Urbana-Champaign, has been appointed Senior Advisor to the Director of the Cancer Center at Illinois (CCIL), Rohit Bhargava.
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Researchers in MIP Explore Link Between Ovarian Cancer and Cholesterol
Led by Sisi He from the Erik Nelson lab, researchers have found that a metabolite of cholesterol (27-hydroxycholesterol; 27HC) was essential for the growth of ovarian tumors in mice.
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Hitting the (Moving) Target of Drug Resistant Cancers
Benita Katzenellenbogen has delved into the causes and treatments for breast cancer and other hormone-dependent cancers for virtually her entire career. Her tireless work in the field has established her as a world-renowned expert.