The Proceedings of the National Academy of Sciences (PNAS) is a peer reviewed journal of the National Academy of Sciences (NAS) that covered biological, physical, and social sciences. 

 

Study offers new insight into powerful inflammatory regulator

A new study in mice reveals how a protein called Brd4 boosts the inflammatory response – for better and for worse, depending on the ailment. The study is the first to show that this protein, while problematic in some circumstances, also can protect the body from infection. The findings are reported...

A study published in PNAS by Prof. Claudio Grosman and Dr. Gisela D. Cymes has revealed the elusive link between amino-acid sequence and charge selectivity in the superfamily of nicotinic acetylcholine receptors.

Here, the authors present compelling evidence for the critical involvement of ionized side chains—whether pore-facing or buried—rather than backbone atoms and propose a mechanism whereby not only their charge sign, but also, their conformation determines charge selectivity.

Team discovers how a cancer-causing bacterium spurs cell death

A new study led by Professor of Microbiology Stephen Blanke, in Proceedings of the National Academy of Sciences, is the first to show how a bacterial toxin can disrupt a cell's mitochondria – its energy-generation and distribution system – to disable the cell and spur apoptosis (programmed cell...

Satish Nair Published in PNAS

Associate Professor of Biochemistry Satish Nair and Biochemistry Affiliate Wilfred van der Donk are corresponding authors on "Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis," appearing in the Proceedings of the National Academy of...

Supriya Prasanth published in PNAS

Assistant Professor of Cell and Developmental Biology Supriya Prasanth is lead and co-corresponding author of a paper published in the Proceedings of the National Academy of Sciences, "Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization." The...