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Douglas A. Mitchell

Profile picture for Douglas A. Mitchell

Contact Information

Department of Chemistry
University of Illinois
361 RAL, Box 22-5
600 South Mathews Avenue
Urbana, IL 61801

John and Margaret Witt Professor of Chemistry
Affiliate Professor, Microbiology

Biography

Professor Mitchell received his undergraduate degree in chemistry from Carnegie Mellon University in 2002. After a short internship in medicinal chemistry at Merck Research Laboratories, he moved to the University of California, Berkeley and worked with Michael Marletta. After earning his PhD in 2006, Professor Mitchell pursued postdoctoral studies with Jack Dixon at the University of California, San Diego. Professor Mitchell joined the University of Illinois faculty in 2009 and has research interests that span the interface of chemistry and biology.

Research Interests

reactivity-based natural product discovery; complex molecule structural elucidation and derivatization; structure-activity relationships and mode of action determination of biomedically important compounds; natural product chemical biology: mechanistic enzymology of key biosynthetic enzymes; structure-function studies of complex small molecules; and development of bioinformatic and bioorganic methodology to accelerate the discovery of biomedically important compounds

Research Description

Our primary objective is to use a blend of chemical and biological approaches to address the alarming rise in antibiotic resistance. In this endeavour, we seek to identify and characterize novel antibiotic compounds. Our research involves the characterization of novel natural products and employs synthetic methods to reveal both biological mode of action and structure-activity relationships. Further, we evaluate the mechanistic details of key biosynthetic enzymes for the purposes of analog generation. Taken together, our work aims to expedite the discovery of future medicines from biological sources. Of special interest are compounds that only kill pathogenic bacteria or directly target mechanisms of virulence. Unlike currently deployed antibiotics, which exclusively target essential life processes, our strategy holds great potential in delaying resistance. The Mitchell laboratory is a multidisciplinary team that draws methodology from the fields of chemical biology, organic chemistry, microbiology, pharmacology, structural biology, and bioinformatics.

For a more detailed research description see: https://mitchell-lab.chemistry.illinois.edu/index.html

Awards and Honors

2015 National Fresenius Award, Phi Lambda Upsilon (National Chemistry Honor Society)
2015 Camille Dreyfus Teacher-Scholar Award
2015-2016 Helen Corley Petit Scholar (UIUC College of Liberal Arts and Sciences)
2015 Pfizer Award in Enzyme Chemistry (ACS Division of Biological Chemistry)
Tomorrow's PI: Genome Technology magazine
Packard Fellowship in Science and Engineering
NIH Director's New Innovator Award

Additional Campus Affiliations

John & Margaret Witt Professor, Chemistry
Alumni Research Scholar, Chemistry
Professor, Chemistry
Professor, Carl R. Woese Institute for Genomic Biology
Affiliate, Microbiology

Recent Publications

Harris, L. A., & Mitchell, D. A. (2022). Reactivity-based screening for natural product discovery. In E. E. Carlson (Ed.), Chemical Microbiology Part B (pp. 177-208). (Methods in Enzymology; Vol. 665). Academic Press Inc.. https://doi.org/10.1016/bs.mie.2021.11.018

Nguyen, D. T., Le, T. T., Rice, A. J., Hudson, G. A., Van Der Donk, W. A., & Mitchell, D. A. (2022). Accessing Diverse Pyridine-Based Macrocyclic Peptides by a Two-Site Recognition Pathway. Journal of the American Chemical Society, 144(25), 11263-11269. https://doi.org/10.1021/jacs.2c02824

Guo, X., Zhang, J., Li, X., Xiao, E., Lange, J. D., Rienstra, C. M., Burke, M. D., & Mitchell, D. A. (2021). Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides. ACS Central Science, 7(5), 781-791. https://doi.org/10.1021/acscentsci.1c00148

Hudson, G. A., Hooper, A. R., Dicaprio, A. J., Sarlah, D., & Mitchell, D. A. (2021). Structure Prediction and Synthesis of Pyridine-Based Macrocyclic Peptide Natural Products. Organic Letters, 23(2), 253-256. https://doi.org/10.1021/acs.orglett.0c02699

Liu, A., Krushnamurthy, P. H., Subramanya, K. S., Mitchell, D. A., & Mahanta, N. (2021). Enzymatic thioamidation of peptide backbones. In E. J. Petersson (Ed.), Synthetic and Enzymatic Modifications of the Peptide Backbone (pp. 459-494). (Methods in Enzymology; Vol. 656). Academic Press Inc.. https://doi.org/10.1016/bs.mie.2021.04.010

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