RNA Biology, Chemical Biology, Epigenetics and Epitranscriptomics, Single-cell Multi-omics, Neurobiology
Our research aims to answer one of neuroscience's central questions: How does the brain’s connection diagram underlie its function? New technologies are required to map the complete wiring diagram of the mammalian brain, reveal the underlying principles of how neurons form connections, and identify connectivity changes induced by experiences, behaviors, and brain disorders. Incorporating transcriptomics and proteomics data into the structural map will help to clarify the underlying molecular mechanisms causing these changes.
The research in our lab centers on the development and application of high-throughput technologies to the study of molecular mechanisms of brain organization and function, specifically by tracking the mammalian brain's connectomic (brain-wide neuronal connection dynamics), transcriptomic, proteomic (spatiotemporal distribution of RNAs and proteins), and epitranscriptomic (dynamic RNA modifications) landscapes over time. Our long-term goal is to gain a comprehensive understanding of the mammalian brain through quantitative methods applied at the systematic, cellular, and molecular levels.
Postdoc, Stanford University, 2017-2023
M.S. and Ph.D., The University of Chicago, 2012-2017
B.S., Peking University, 2008-2012
Awards and Honors
2022 Highly Cited Researcher in the field of Molecular Biology and Genetics – 2022, Web of Science
2021 Highly Cited Researcher in the field of Cross-Field – 2021, Web of Science
2019 Life Sciences Research Foundation Shurl and Kay Curci Foundation Postdoctoral Fellowship
2018 Stanford ChEM-H Postdocs at the Interface Seed Grant, Stanford University
2018 Extraordinary Prize of the 2017 Chinese Government Award for Outstanding Self-Financed Students Abroad
2017 Wu Tsai Neurosciences Institute Interdisciplinary Scholar Awards, Stanford University
2017 Scaringe Graduate Student Career Award, The RNA Society
2017 Elizabeth R. Norton Prize for Excellence in Research in Chemistry, The University of Chicago
2017 GLCACS Outstanding Student Research Award, Chinese American Chemical Society
2017 William Rainey Harper Dissertation Fellowship, The University of Chicago
2016 Collège de France Science Research Travel Grants for Doctoral Research in Paris, France Chicago Center
2016 Joan Shiu Chemistry Department Student Service Award, The University of Chicago
2015 The Albert J. Cross Prize for Excellence in Research, Teaching, and Department Citizenship, The University of Chicago
2014 Howard Hughes Medical Institute International Predoctoral Student Fellowship
2012 First Prize of the inaugural “Star of Chemistry” Undergraduate Selection of College of Chemistry, Peking University, China
2011 Grand Prize of 12th "Challenge Cup" National Science and Technology Academic Competition, China
Additional Campus Affiliations
Assistant Professor, Cell and Developmental Biology
- S Han*, BS Zhao*, SA Myers, SA Carr, C He, AY Ting. RNA–protein interaction mapping via MS2- or Cas13-based APEX targeting. Proc. Natl. Acad. Sci. U.S.A., 117(36), 22068-22079 (2020).
- BS Zhao*, X Wang*, AC Beadell*, Z Lu, H Shi, RK Ho, C He. m6A-dependent Maternal mRNA Clearance Facilitates Maternal-to-Zygotic Transition in Zebrafish, Nature, 542 (7642), 475-478 (2017).
- BS Zhao, IA Roundtree, C He. Post-Transcriptional Gene Regulation by mRNA Modifications, Nat. Rev. Mol. Cell Biol., 18, 31-42 (2017).
- X Wang*, BS Zhao*, IA Roundtree, Z Lu, D Han, H Ma, X Weng, K Chen, H Shi, C He. N6-methyladenosine Modulates Messenger RNA Translation Efficiency, Cell, 161(6), 1388–1399 (2015).
Lee, S. Y., Cheah, J. S., Zhao, B., Xu, C., Roh, H., Kim, C. K., Cho, K. F., Udeshi, N. D., Carr, S. A., & Ting, A. Y. (2023). Engineered allostery in light-regulated LOV-Turbo enables precise spatiotemporal control of proximity labeling in living cells. Nature Methods, 20(6), 908-917. https://doi.org/10.1038/s41592-023-01880-5
Han, S., Zhao, B. S., Myers, S. A., Carr, S. A., He, C., & Ting, A. Y. (2020). RNA-protein interaction mapping via MS2- or Cas13-based APEX targeting. Proceedings of the National Academy of Sciences of the United States of America, 117(36), 22068-22079. https://doi.org/10.1073/pnas.2006617117
Liu, C., Cui, X., Zhao, B. S., Narkhede, P., Gao, Y., Liu, J., Dou, X., Dai, Q., Zhang, L. S., & He, C. (2020). DNA 5-Methylcytosine-Specific Amplification and Sequencing. Journal of the American Chemical Society, 142(10), 4539-4543. https://doi.org/10.1021/jacs.9b12707
Lu, M., Zhang, Z., Xue, M., Zhao, B. S., Harder, O., Li, A., Liang, X., Gao, T. Z., Xu, Y., Zhou, J., Feng, Z., Niewiesk, S., Peeples, M. E., He, C., & Li, J. (2020). N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I. Nature Microbiology, 5(4), 584-598. https://doi.org/10.1038/s41564-019-0653-9
Huang, H., Weng, H., Zhou, K., Wu, T., Zhao, B. S., Sun, M., Chen, Z., Deng, X., Xiao, G., Auer, F., Klemm, L., Wu, H., Zuo, Z., Qin, X., Dong, Y., Zhou, Y., Qin, H., Tao, S., Du, J., ... Chen, J. (2019). Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally. Nature, 567(7748), 414-419. https://doi.org/10.1038/s41586-019-1016-7