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Investigating the role of Brd4 in diet-induced obesity
A new study, published in JCI insight, looks at how Brd4, a regulator of the innate immune response, influences diet-induced obesity. The researchers believe that Brd4 could be used as a target for obesity and insulin resistance.
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Piecing together the LanCL puzzle
Researchers from the Carl R. Woese Institute for Genomic Biology, including several faculty in the School of Molecular & Cellular Biology, in collaboration with scientists at Oxford University have published a paper in Cell reporting the function of LanCL proteins. These proteins...
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MCB students, faculty, and staff recognized for their extraordinary efforts during COVID-19
We’re proud to share the news that many School of Molecular & Cellular Biology students, faculty, and staff members have received College of Liberal Arts & Sciences Impact Awards. The awards, announced this week, recognize inspiring efforts during the COVID-19 pandemic. So many in our...
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Researchers structurally characterize a dual-function transporter
The regulation of glutamate, an excitatory neurotransmitter abundant in the central nervous system, is critical for maintaining normal brain function. Glutamate regulation is achieved via extracellular transport of the amino acid. There are two primary classes of proteins involved in the transport...
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MCB statement on solidarity with Asian American communities
The MCB community stands together in denouncing all acts of hate against Asians and Asian Americans, just as we denounce all acts of intolerance and hate within and outside our MCB community. We stand in solidarity with our Asian and Asian American colleagues against the forces of intolerance and...
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Division of labor within regenerating liver maintains metabolism, mouse study finds
The liver has a rare superpower among body organs – the ability to regenerate, even if 70% of its mass is removed. It also keeps up its metabolic and toxin-removing work during the process of regeneration, thanks to a subset of cells that expand their workload while the rest focus on multiplication...
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Researchers examine the biological role of epigenetic regulator Brd4 in inflammasome activation
Inflammasomes play a critical role in the innate cellular immune response to pathogen infection. The inflammasome, a cytosolic multiprotein complex, recognizes substrates produced during infection or tissue damage, and triggers an inflammatory response by releasing the proinflammatory cytokine IL-...
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Cronan lab uncovers mechanism for synthesis of pimelate moiety, the biotin precursor
Professor John. E. Cronan, Microbiology Alumni Professor and professor of biochemistry at the University of Illinois, is a leading researcher and innovator in the field of lipid metabolism. His recent work focuses on the synthesis of biotin and its building blocks across different species of...
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Wu and collaborators develop new molecules which attack the virus that causes COVID-19 and resist 'escape' mutations
An international team of researchers including Nicholas Wu, a professor in the Department of Biochemistry, has published a new study which developed highly potent molecules that can neutralize SARS-CoV-2 by simultaneously targeting multiple sites of vulnerability on the virus.
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New study: MCB faculty among world's most influential researchers
Several faculty from the School of Molecular & Cellular Biology were among the most-cited researchers in the world in a new, widely hailed analysis designed to provide a clearer view of scientific and scholarly impact.