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Research Publications

Stories about recent journal articles featuring work by MCB faculty and students.

New antibiotic kills pathogenic bacteria, spares healthy gut microbes

Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the mouse gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides...

New study highlights need for cell-type-specific therapies in treatment of HIV

Researchers from the University of Illinois have demonstrated the importance of cell-type-specific targeting in the treatment of HIV. Their findings, published in PNAS, are one of the first to examine the differential or cell-type...

Researchers decode movement pattern of landmark polar protein

A trio of researchers from the Department of Microbiology has discovered an essential function of a landmark protein in regulating movement across bacterial cells. Members of the Mera Lab determined how the coiled-coil polar protein TipN moves a region of the chromosome called parS. They also...

Researchers identify key regulators underlying regeneration in Drosophila

Some animals possess the remarkable ability to regenerate lost structures, exemplified by a lizard regrowing its tail. However, this regenerative process must be tightly regulated by the body to ensure proper tissue organization and to prevent abnormal growths, such as cancer. Yet, the precise...

New study uncovers novel receptor function in Fragile X syndrome

Fragile X syndrome is one of the most commonly inherited forms of autism and intellectual disability, and no treatment currently exists. But a team of University of Illinois researchers led by Vipendra Kumar, a postdoctoral researcher in the Department of Molecular & Integrative Physiology, has...

Mice study suggests metabolic diseases may be driven by gut microbiome, loss of ovarian hormones

The gut microbiome interacts with the loss of female sex hormones to exacerbate metabolic disease, including weight gain, fat in the liver and the expression of genes linked with inflammation, researchers found in a new rodent study. The findings, published in the journal...

Unveiling the Role of SNUL RNAs in Ribosomal RNA Expression Regulation

A new study by University of Illinois scientist Dr. Kannanganattu V. Prasanth and his team of researchers at Illinois and across multiple institutions has shed light on a novel family of noncoding RNAs (ncRNAs), and their significant...

Supercomputing the secrets inside cattle antibiotics

Chemists have determined for the first time the crystal structure and unlocked the mechanism of reaction activity of a key component of the monensin enzyme.  “The main finding was the first crystal structure for this family of enzymes,” said...

Structural study of mucosal antibody reveals unexpected host-pathogen interactions

Secretory Immunoglobulin A (SIgA), the predominant human mucosal antibody, can bind to bacterial surface proteins and trigger an immune response to...

Chen lab uncovers new insights, new player in immune system defense

When confronted with infection or injury, our body rallies to fight and heal itself and inflammation is a key part of this early defense system. But inflammation can also go awry, as exhibited in chronic illnesses such as obesity and type 2 diabetes. Biochemistry professor...