Image
Jongsook Kim Kemper Lab: Novel regulatory pathways in the liver for maintenance of metabolic homeostasis in mice
The Kemper lab has recently published two high-profile papers on metabolic regulation in the Journal of Clinical Investigation and Nature Communications.
Image
Study: Protein found to be key component in irregularly excited brain cells
Research scientist Kwan Young Lee, molecular and integrative physiology professor Nien-Pei Tsai, and their colleagues discovered that an overabundance of the tumor suppressor protein p53 in neurons can lead to impaired regulation of neuronal excitability in a mouse model of Fragile X syndrome.
Image
Study reveals a novel target for the treatment of breast cancer
The proliferation and differentiation of the mammary gland is a process tightly controlled by hormones and growth factors. Dysregulation of the signaling pathways that orchestrate mammary gland development is frequently linked to the excessive, unchecked proliferation associated with breast cancer...
Image
Virtual predator is self-aware, behaves like living counterpart
Rhanor Gillette and his colleagues built a virtual ocean predator that has simple self-awareness.
Image
Researchers identify new physiological regulators of the one carbon cycle metabolism. The findings were published in Nature Communications.
Professor of Molecular and Integrative Physiology, Jongsook Kim Kemper and the first and co-corresponding author, Young Kim, co-author Sangwon Byun, and colleagues demonstrated that Aromatic Hydrocarbon Receptor (AHR) and the orphan nuclear receptor, Small Heterodimer Partner (SHP), have an...
Image
Chung Lab: Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.
New findings suggest that novel down-regulation of GIRK channels by caspase-3 may contribute to NMDAR-dependent hippocampal atrophy following chronic epileptic seizures
Image
Professor Llano Becomes Professorial Scholar
Dan Llano was recently appointed the Benjamin R. and Elinor W. Bullock and Edwin E. and Jeanne Bullock Goldberg Professorial Scholar in the Department of Molecular and Integrative Physiology in the School of Molecular and Cellular Biology. Llano is an associate professor in MIP and a member of the...
Image
Hitting the (Moving) Target of Drug Resistant Cancers
Benita Katzenellenbogen has delved into the causes and treatments for breast cancer and other hormone-dependent cancers for virtually her entire career. Her tireless work in the field has established her as a world-renowned expert.
Image
Uncovering a Way to Fight Fatty Liver Disease
The Anakk lab explored the mechanism by which the liver can be protected from developing fatty liver disease. This work was also published in Hepatology and led by two former undergraduates of the MCB program, Oludemilade Akinrotimi (Demi) and Ryan...
Image
Exploring the Effect of Liver Disease on the Heart
Using mouse models that resembled the clinical cholestasis, or very high levels of bile acids in the liver, Dr. Sayee Anakk, with graduate student and first author Bhoomika Mathur, observed the effect of cholestasis on a key indicator of heart health.