The Grosman and Tajkhorshid labs collaborate on "Chasing the open-state structure of pentameric ligand-gated ion channels." Their findings are presented as the cover story in the December Issue of The Journal of General Physiology.

The study, reported in Nature Communications, identifies new potential drug targets that could inhibit the creation or actions of the dangerous cholesterol byproduct.

A new study published in Development by Assistant Professor Eric Bolton and Research Associate Hyun-Jung Park reveals that glial cell line-derived neurotrophic factor (GDNF), which signals through activation of RET tyrosine kinase, inhibits androgen-induced development of the mouse prostate gland.

Professor Bagchi is the Deborah Paul Professor of Molecular and Cellular Biology and current department head of Molecular and Integrative Physiology. Bagchi is an accomplished scholar and leader, and has provided a clear strategic vision statement for the research and teaching missions of MCB.

Molecular and Integrative Physiology Professor Jongsook Kemper, postdoctoral fellow Sangwon Byun (leading author of the study), research scientist Young Kim, and colleagues publish results in the EMBO Journal.

Lysosome-mediated autophagy is essential for cellular survival by recycling cytoplasmic components under nutrient-deprived conditions and removing damaged organelles in cells, but must be suppressed in nutrient-rich conditions to prevent unnecessary breakdown of cellular components. Molecular and...

Epilepsy is a medical condition characterized by spontaneous seizures due to hyperexcitability of brain neurons. Assistant Professor Nien-Pei Tsai, graduate student Jiuhe Zhu and colleagues uncovered that an insufficient function or mutations of a novel epilepsy-associated gene Nedd4-2 leads to...

A new era has dawned in understanding neuropathological disorders such as epilepsy, schizophrenia, depression, and autism spectrum disorders. These disorders, traditionally classified in the Diagnostic and Statistical Manual of Mental Disorders by the American Psychiatric Society, are now being re-...

Frank continues to visit the Department of Molecular and Integrative Physiology and to lend his support and expertise. “The Department of Molecular and Integrative Physiology is a small, but strong department, that is central to the research and educational missions of the School of MCB and the...

The infinitely complex workings of the human brain have intrigued researchers for centuries. Our understanding of its workings have been limited, not by our curiosity, but by our tools. Now, with the growth of new molecular biology and genomics approaches, big data, and engineering advances that...