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Study: Protein found to be key component in irregularly excited brain cells
Research scientist Kwan Young Lee, molecular and integrative physiology professor Nien-Pei Tsai, and their colleagues discovered that an overabundance of the tumor suppressor protein p53 in neurons can lead to impaired regulation of neuronal excitability in a mouse model of Fragile X syndrome.
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Study reveals a novel target for the treatment of breast cancer
The proliferation and differentiation of the mammary gland is a process tightly controlled by hormones and growth factors. Dysregulation of the signaling pathways that orchestrate mammary gland development is frequently linked to the excessive, unchecked proliferation associated with breast cancer...
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Virtual predator is self-aware, behaves like living counterpart
Rhanor Gillette and his colleagues built a virtual ocean predator that has simple self-awareness.
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Researchers identify new physiological regulators of the one carbon cycle metabolism. The findings were published in Nature Communications.
Professor of Molecular and Integrative Physiology, Jongsook Kim Kemper and the first and co-corresponding author, Young Kim, co-author Sangwon Byun, and colleagues demonstrated that Aromatic Hydrocarbon Receptor (AHR) and the orphan nuclear receptor, Small Heterodimer Partner (SHP), have an...
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Chung Lab: Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.
New findings suggest that novel down-regulation of GIRK channels by caspase-3 may contribute to NMDAR-dependent hippocampal atrophy following chronic epileptic seizures
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Professor Llano Becomes Professorial Scholar
Dan Llano was recently appointed the Benjamin R. and Elinor W. Bullock and Edwin E. and Jeanne Bullock Goldberg Professorial Scholar in the Department of Molecular and Integrative Physiology in the School of Molecular and Cellular Biology. Llano is an associate professor in MIP and a member of the...
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Hitting the (Moving) Target of Drug Resistant Cancers
Benita Katzenellenbogen has delved into the causes and treatments for breast cancer and other hormone-dependent cancers for virtually her entire career. Her tireless work in the field has established her as a world-renowned expert.
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Uncovering a Way to Fight Fatty Liver Disease
The Anakk lab explored the mechanism by which the liver can be protected from developing fatty liver disease. This work was also published in Hepatology and led by two former undergraduates of the MCB program, Oludemilade Akinrotimi (Demi) and Ryan...
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Exploring the Effect of Liver Disease on the Heart
Using mouse models that resembled the clinical cholestasis, or very high levels of bile acids in the liver, Dr. Sayee Anakk, with graduate student and first author Bhoomika Mathur, observed the effect of cholestasis on a key indicator of heart health.
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The Grosman and Tajkhorshid labs collaborate on "Chasing the open-state structure of pentameric ligand-gated ion channels"
The Grosman and Tajkhorshid labs collaborate on "Chasing the open-state structure of pentameric ligand-gated ion channels." Their findings are presented as the cover story in the December Issue of The Journal of General Physiology.