Molecular & Integrative Physiology (MIP)

Uncovering a Way to Fight Fatty Liver Disease

2017-12-31

The Anakk lab explored the mechanism by which the liver can be protected from developing fatty liver disease. This work was also published in Hepatology and led by two former undergraduates of the MCB program, Oludemilade Akinrotimi (Demi) and Ryan...

Exploring the Effect of Liver Disease on the Heart

2017-12-31

Using mouse models that resembled the clinical cholestasis, or very high levels of bile acids in the liver, Dr. Sayee Anakk, with graduate student and first author Bhoomika Mathur, observed the effect of cholestasis on a key indicator of heart health.

The Grosman and Tajkhorshid labs collaborate on "Chasing the open-state structure of pentameric ligand-gated ion channels"

2017-12-05

The Grosman and Tajkhorshid labs collaborate on "Chasing the open-state structure of pentameric ligand-gated ion channels." Their findings are presented as the cover story in the December Issue of The Journal of General Physiology.

Cholesterol byproduct hijacks immune cells, lets breast cancer spread

2017-10-12

The study, reported in Nature Communications, identifies new potential drug targets that could inhibit the creation or actions of the dangerous cholesterol byproduct.

Glial cell line-derived neurotrophic factor signaling inhibits development of the prostate gland

2017-08-25

A new study published in Development by Assistant Professor Eric Bolton and Research Associate Hyun-Jung Park reveals that glial cell line-derived neurotrophic factor (GDNF), which signals through activation of RET tyrosine kinase, inhibits androgen-induced development of the mouse prostate gland.

Milan Bagchi appointed new director of the School of Molecular and Cellular Biology

2017-06-02

Professor Bagchi is the Deborah Paul Professor of Molecular and Cellular Biology and current department head of Molecular and Integrative Physiology. Bagchi is an accomplished scholar and leader, and has provided a clear strategic vision statement for the research and teaching missions of MCB.

Researchers uncover a nutrient-sensing epigenetic pathway that controls autophagy

2017-05-17

Molecular and Integrative Physiology Professor Jongsook Kemper, postdoctoral fellow Sangwon Byun (leading author of the study), research scientist Young Kim, and colleagues publish results in the EMBO Journal.

Professor Jongsook Kemper’s group uncover a nutrient-sensing epigenetic pathway that controls autophagy

2017-05-09

Lysosome-mediated autophagy is essential for cellular survival by recycling cytoplasmic components under nutrient-deprived conditions and removing damaged organelles in cells, but must be suppressed in nutrient-rich conditions to prevent unnecessary breakdown of cellular components. Molecular and...

Assistant Professor Nien-Pei Tsai’s lab has published a study in PLOS Genetics on how a novel epilepsy-associated gene controls neuronal excitability

2017-02-28

Epilepsy is a medical condition characterized by spontaneous seizures due to hyperexcitability of brain neurons. Assistant Professor Nien-Pei Tsai, graduate student Jiuhe Zhu and colleagues uncovered that an insufficient function or mutations of a novel epilepsy-associated gene Nedd4-2 leads to...

Neuronal Excitability in Health and Disease

2016-12-31

A new era has dawned in understanding neuropathological disorders such as epilepsy, schizophrenia, depression, and autism spectrum disorders. These disorders, traditionally classified in the Diagnostic and Statistical Manual of Mental Disorders by the American Psychiatric Society, are now being re-...

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