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Cholesterol metabolite induces production of cancer-promoting vesicles
Scientists working to understand the cellular processes linking high cholesterol to breast cancer recurrence and metastasis report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound...
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New study identifies culprit behind onion rot: the chemical pantaphos, which is toxic to some brain cancer cells, could also have biomedical applications
Since 1983, the bacteria Pantoea ananatis has been known to infect several important crops including onions, rice, and corn. It was unclear, however, what molecules were involved. A new study, published in mBio, has identified one of the culprits: pantaphos. Intriguingly, the researchers have...
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Division of labor within regenerating liver maintains metabolism, mouse study finds
The liver has a rare superpower among body organs – the ability to regenerate, even if 70% of its mass is removed. It also keeps up its metabolic and toxin-removing work during the process of regeneration, thanks to a subset of cells that expand their workload while the rest focus on multiplication...
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Unraveling mechanisms of FXR in protection against liver diseases
Obesity is rising in prevalence and poses a major concern for the health of our general population. Currently affecting over one-third of the population of the United States, obesity is often comorbid with other diseases, such as diabetes, fatty liver disease, cardiovascular disease, and some...
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Welcome to Professor Nicholas Wu
Professor Wu was one of ten new faculty hires made in the School of Molecular and Cellular Biology in the last three years. Wu is an assistant professor of and is an affiliate of the Carl R. Woese Institute for Genomic Biology.
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Meet MCB: Professor Erik Nelson
Dr. Nelson’s lab focuses on determining how different hormones and metabolite factors impact breast and ovarian cancer progression.
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Following Drg: Curiosity Drives Scientist’s Protein Synthesis Research
Current cancer treatments include drugs that target standard protein synthesis in cells, which can kill cancer cells, but also targets healthy cells. To address this issue, associate professor of biochemistry and Cancer Center at Illinois (CCIL) member, Hong Jin, is focusing on a non-canonical...
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Erik Nelson receives $4.5M grant to study prevention and treatment of metastatic breast cancer
Erik Nelson, professor of molecular and integrative physiology, has won a $4.5 million Era of Hope Scholar Award from the United States Department of Defense Breast Cancer Research Program.This prestigious award supports individuals early in their careers who have demonstrated significant potential...
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Cholesterol metabolite causes immune system to attack T cells instead of breast cancer, study finds
In breast cancer tumors, a molecule produced when the body breaks down cholesterol hijacks the myeloid immune cells that normally arm T cells to fight cancer, a new study in mice found. Instead, the hijacked myeloid cells disarm the T cells and even tell them to self-destruct.
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Researchers: Breast Cancer Deadlier in Heart Attack Survivors
Breast cancer patients are 60 percent more likely to die of cancer after surviving a heart attack, according to a new study published in Nature Medicine.