Cancer

Cholesterol metabolite causes immune system to attack T cells instead of breast cancer, study finds

2020-09-15

In breast cancer tumors, a molecule produced when the body breaks down cholesterol hijacks the myeloid immune cells that normally arm T cells to fight cancer, a new study in mice found. Instead, the hijacked myeloid cells disarm the T cells and even tell them to self-destruct.

Researchers: Breast Cancer Deadlier in Heart Attack Survivors

2020-07-15

Breast cancer patients are 60 percent more likely to die of cancer after surviving a heart attack, according to a new study published in Nature Medicine.

Engineered immune cells recognize, attack human and mouse solid-tumor cancer cells

2020-06-29

Silhouette of Preeti Sharma holding up a 250 ml pyrex vial with a bit of liquid inside against a window.

A method known as CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia. It modifies a patient’s own T-cells by adding a piece of an antibody that recognizes unique features on the surface of cancer cells. In a new study, researchers report that they...

MIP Professor Benita Katzenellenbogen named Senior Advisor for the Cancer Center at Illinois

2020-06-24

Benita S. Katzenellenbogen, Professor of Molecular and Integrative Physiology at the University of Illinois at Urbana-Champaign, has been appointed Senior Advisor to the Director of the Cancer Center at Illinois (CCIL), Rohit Bhargava.

Liqian Ma awarded Mead Graduate Fellowship

2020-06-17

The University of Illinois School of Molecular and Cellular Biology is pleased to announce the inaugural recipient of the Julie and David Mead Graduate Fellowship.

Erik Nelson named Gunsalus Scholar

2020-02-20

Erik Nelson, Assistant Professor of Molecular and Integrative Physiology, has been named the 2020-2021 Gunsalus Scholar by the College of Liberal Arts and Sciences for his work on cholesterol metabolism and cancer.

New compounds block master regulator of cancer growth, metastasis

2020-01-07

Scientists have developed new drug compounds that thwart the pro-cancer activity of FOXM 1, a transcription factor that regulates the activity of dozens of genes. The new compounds suppress tumor growth in human cells and in mouse models of several types of human breast cancer.

Researchers in MIP Explore Link Between Ovarian Cancer and Cholesterol

2019-07-31

Led by Sisi He from the Erik Nelson lab, researchers have found that a metabolite of cholesterol (27-hydroxycholesterol; 27HC) was essential for the growth of ovarian tumors in mice.

Shapiro lab: Investigating breast cancer metastasis

2019-04-07

The latest paper by the Shapiro lab looks at the effect of mutations in the estrogen receptor on the growth and spread of breast cancer cells. The findings were published in a paper titled "Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells...

Mutations in noncoding genes could play big role in regulating cancer, study finds

2019-03-14

Professor Kannanganattu Prasanth led a team that found that certain genes that don’t code for proteins could play an important regulatory role in breast cancer.

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