Cancer

The University of Illinois School of Molecular and Cellular Biology is pleased to announce the inaugural recipient of the Julie and David Mead Graduate Fellowship.

Erik Nelson, Assistant Professor of Molecular and Integrative Physiology, has been named the 2020-2021 Gunsalus Scholar by the College of Liberal Arts and Sciences for his work on cholesterol metabolism and cancer.

Scientists have developed new drug compounds that thwart the pro-cancer activity of FOXM 1, a transcription factor that regulates the activity of dozens of genes. The new compounds suppress tumor growth in human cells and in mouse models of several types of human breast cancer.

Led by Sisi He from the Erik Nelson lab, researchers have found that a metabolite of cholesterol (27-hydroxycholesterol; 27HC) was essential for the growth of ovarian tumors in mice.

The latest paper by the Shapiro lab looks at the effect of mutations in the estrogen receptor on the growth and spread of breast cancer cells. The findings were published in a paper titled "Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells...

Professor Kannanganattu Prasanth led a team that found that certain genes that don’t code for proteins could play an important regulatory role in breast cancer.

Discovery provides deeper insight into DNA and the fight against cancer.

The Prasanths began a new life as postdoctoral researchers at Cold Spring Harbor Laboratory in New York. And today, as University of Illinois CDB professors, they continue to work side by side — literally. Their respective labs are next to each other in the Chemical and Life Sciences Building...

Prasanth’s lab published several papers on a particular lncRNA called MALAT1, with significant findings showing an important link between cancer and MALAT1. They found that when MALAT1 is overexpressed in breast cells, the cells form tumors. Conversely, when it is depleted in breast cancer cells,...

The Kranz lab and colleagues have recently publish a trio of papers that describe the engineering of receptors that can mediate specific and potent destruction of cancers by T cells.