MCB researchers uncover a novel mechanism of STAT3 activation in cancer

Pallob Barai and Reean Abdullah at the lab bench
One day, on assignment researching non-canonical functions of aminoacyl-tRNA synthetases — housekeeping enzymes essential for protein synthesis — Pallob Barai noticed an intriguing pattern.“A particular AARS enzyme, TARS1, was found to be correlated with poor patient survival in different cancers,...

MCB scientists’ discovery begets new insights into cancer tumor growth

Song and Prasanth
New research from the K.V. Prasanth lab, in collaboration with scientists across the University of Illinois and other institutions, has revealed that gene positioning near nuclear speckles — key nuclear domains that promote gene expression — along with the mechanistic functions of the non-coding...

A cellular protein, FGD3, boosts breast cancer chemotherapy, immunotherapy

Six researchers gather in a lab
A naturally occurring protein that tends to be expressed at higher levels in breast cancer cells boosts the effectiveness of some anticancer agents, including doxorubicin, one of the most widely used chemotherapies, and a preclinical drug known as ErSO, researchers report. The protein, FGD3,...