New drug stalls estrogen receptor-positive cancer cells and shrinks tumors

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Biochemistry researchers in Dr. David Shapiro's lab, and a study team including researchers from the department of food science and human nutrition, the department of molecular and integrative physiology, the College of Medicine and the Cancer Center, have developed a new drug that kills estrogen...

New drug compounds show promise against endometriosis

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An interdisciplinary research team, including molecular and integrative physiology professors Benita Katzenellenbogen and Milan Bagchi, has developed a new approach to treating endometriosis. Their research appears in Science Translational Medicine.

Scientists engineer human T cell receptors against cancer antigens

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Graduate student Sheena Smith and Professor David Kranz of the Department of Biochemistry have developed an approach to discover T cell receptors that could be therapeutically useful against different cancers. In collaboration with graduate students Yuhang Wang and Javier Baylor and Professor Emad...

Team finds mechanism linking key inflammatory marker to cancer

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In a new study described in the journal Oncogene, Professor of Biochemistry Lin-Feng Chen and his team reveal how a key player in cell growth, immunity and the inflammatory response can be transformed into a primary contributor to tumor growth.

Team discovers how a cancer-causing bacterium spurs cell death

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A new study led by Professor of Microbiology Stephen Blanke, in Proceedings of the National Academy of Sciences, is the first to show how a bacterial toxin can disrupt a cell's mitochondria – its energy-generation and distribution system – to disable the cell and spur apoptosis (programmed cell...

Cancer-causing bacterium targets tumor-suppressor protein

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Assistant Professor of Biochemistry Lin-Feng Chen and colleagues have discovered a mechanism by which Helicobacter pylori, the only known cancer-causing bacterium, disables a tumor suppressor protein in host cells.