Autophagy or “self-eating” is a fundamental biological process by which cells digest and recycle cellular components for survival of the cells under nutrient-deprived conditions. Autophagy must be tightly controlled since deficient autophagy is associated with many diseases and aging, while...

The Anakk lab has investigated the metabolic repercussions of deleting the scaffolding protein IQGAP1. These findings were published in a paper entitled "Identification of IQ motif-containing GTPase Activating Protein 1 as a regulator of long-term ketosis" in JCI Insight.

The Kemper lab has recently published two high-profile papers on metabolic regulation in the Journal of Clinical Investigation and Nature Communications.

The Anakk lab explored the mechanism by which the liver can be protected from developing fatty liver disease. This work was also published in Hepatology and led by two former undergraduates of the MCB program, Oludemilade Akinrotimi (Demi) and Ryan...

Using mouse models that resembled the clinical cholestasis, or very high levels of bile acids in the liver, Dr. Sayee Anakk, with graduate student and first author Bhoomika Mathur, observed the effect of cholestasis on a key indicator of heart health.

Through the ages, fertility has played a central role in civilizations. Its cultural, socioeconomic, demographic, religious and global implications were and still are incalculable. A Wikipedia search for “fertility gods,” for example, yields a list of 35 cultures with one, and often...