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Proceedings of the National Academy of Sciences (PNAS)

The Proceedings of the National Academy of Sciences (PNAS) is a peer reviewed journal of the National Academy of Sciences (NAS) that covered biological, physical, and social sciences. 


Wind-chill out! Researchers discover how flow stresses out bacterial pathogens

Researchers have discovered the addition of fluid to human pathogens triggers a "windchill-like" effect that sensitizes cells to hydrogen peroxide, a well-known agent of cell stress and DNA damage. Their findings have been published in PNAS.

A different kind of cell signal: New method enables clear, precise imaging of human cells

Researchers at the Beckman Institute for Advanced Science and Technology have developed an innovative way to ‘see’ the fine structure and chemical composition of a human cell with unmatched clarity and precision. Their technique, which appeared in PNAS earlier this week, takes a creative — and...

Illinois researchers test nicotinic hypothesis of COVID-19

Although researchers have learned much about SARS-CoV-2, the vast array of unexplained symptoms associated with acute and post-acute ("long") COVID-19 warrants the search for additional biochemical pathways involved. On the basis of amino-acid sequence analyses and computational approaches, it has...

Lethal damage to the ribosome, arguably the most important machinery in living organisms, can be repaired

New research from University of Illinois biochemistry professor Raven Huang reveals that lethal ribosomal damage in bacteria can be reversed by a pair of bacterial enzymes named PrfH and RtcB. The finding raises the question of whether similar ribosomal damage can also be repaired in humans because...

Researchers illuminate the important roles played by extracellular vesicles in early pregnancy

Deciphering the molecular basis of cell-cell communications during early pregnancy has long been a challenge of reproductive scientists. New research from the University of Illinois further illuminates the fascinating dialogue between the developing embryo and endometrium by shedding new light on...

Small molecule transports iron in mice, human cells to treat some forms of anemia

A natural small molecule derived from a cypress tree can transport iron in live mice and human cells lacking the protein that normally does the job, easing a buildup of iron in the liver and restoring hemoglobin and red blood cell production, a new study found.

Study identifies key regulator of cell differentiation

Embryonic stem cells and other pluripotent cells divide rapidly and have the capacity to become nearly any cell type in the body. Scientists have long sought to understand the signals that prompt stem cells to switch off pluripotency and adopt their final functional state.

'Molecular Velcro' enables tissues to sense, react to mechanical force

The Velcro-like cellular proteins that hold cells and tissues together also perform critical functions when they experience increased tension. A new University of Illinois Urbana-Champaign study observed that when tugged upon in a controlled manner, these proteins – called cadherins – communicate...

Researchers characterize natively bound lipids of a pentameric ligand-gated ion-channel in intact fragments of membrane

Many researchers have postulated that the lipid composition of the membrane containing ion channels is critical for function. However, there are limited data about the structure and function of natively bound lipids. Some molecular simulation experiments have provided some insight; but, data from...

Structure matters over sequence for cys-loop cell receptors

Cells communicate with each other by sending, receiving, and decoding signals. Signals that cannot cross the cell membrane directly – such as ions, water-soluble small molecules, and peptides – need to be detected by receptor proteins on the cell’s outer surface.