New therapeutic target identified for triple-negative breast cancer

Gloved hands working with a pipette. Person's face can't be seen. They are in a lab coat and the background is a lab.
Breast cancer is categorized into three major subtypes: hormone receptor-positive, HER2-positive, and triple-negative. Although there are targeted therapeutic approaches for the first two, there are limited options for triple negative-breast cancer patients. In a new study, researchers have...

Professor reflects on decades of breast cancer research, sees hopeful future

In a black and white photo, Benita S. Katzenellenbogen smiles for camera while sitting in lab.
For decades, Professor Benita S. Katzenellenbogen has focused on understanding breast cancer and women’s health, collaborating with scientists on campus and around the world to develop better treatments and reduce morbidities from the disease. Her research has provided the framework for the...

New approach eradicates breast cancer in mice

Researchers discovered a small molecule, ErSO, that eradicates breast cancers in mice by targeting a pathway that protects cancer cells. Photo by L. Brian Stauffer
A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks even large tumors to undetectable levels.

Cholesterol metabolite induces production of cancer-promoting vesicles

Headshot of Erik Nelson
Scientists working to understand the cellular processes linking high cholesterol to breast cancer recurrence and metastasis report that a byproduct of cholesterol metabolism causes some cells to send out cancer-promoting signals to other cells. These signals are packaged in membrane-bound...