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Cholesterol metabolite causes immune system to attack T cells instead of breast cancer, study finds
In breast cancer tumors, a molecule produced when the body breaks down cholesterol hijacks the myeloid immune cells that normally arm T cells to fight cancer, a new study in mice found. Instead, the hijacked myeloid cells disarm the T cells and even tell them to self-destruct.
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Researchers: Breast Cancer Deadlier in Heart Attack Survivors
Breast cancer patients are 60 percent more likely to die of cancer after surviving a heart attack, according to a new study published in Nature Medicine.
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MIP Professor Benita Katzenellenbogen named Senior Advisor for the Cancer Center at Illinois
Benita S. Katzenellenbogen, Professor of Molecular and Integrative Physiology at the University of Illinois at Urbana-Champaign, has been appointed Senior Advisor to the Director of the Cancer Center at Illinois (CCIL), Rohit Bhargava.
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Liqian Ma awarded Mead Graduate Fellowship
The University of Illinois School of Molecular and Cellular Biology is pleased to announce the inaugural recipient of the Julie and David Mead Graduate Fellowship.
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Erik Nelson named Gunsalus Scholar
Erik Nelson, Assistant Professor of Molecular and Integrative Physiology, has been named the 2020-2021 Gunsalus Scholar by the College of Liberal Arts and Sciences for his work on cholesterol metabolism and cancer.
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New compounds block master regulator of cancer growth, metastasis
Scientists have developed new drug compounds that thwart the pro-cancer activity of FOXM 1, a transcription factor that regulates the activity of dozens of genes. The new compounds suppress tumor growth in human cells and in mouse models of several types of human breast cancer.
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Shapiro lab: Investigating breast cancer metastasis
The latest paper by the Shapiro lab looks at the effect of mutations in the estrogen receptor on the growth and spread of breast cancer cells. The findings were published in a paper titled "Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells...
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Mutations in noncoding genes could play big role in regulating cancer, study finds
Professor Kannanganattu Prasanth led a team that found that certain genes that don’t code for proteins could play an important regulatory role in breast cancer.
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Employing the Help of the BHPI Molecule to Boost Anti-Cancer Drug Treatments
For decades, MCB and the University of Illinois have been at the forefront of understanding the role of estrogen and the estrogen receptor (ER) in causing breast cancer. This is essential work: Breast cancer is the most commonly diagnosed cancer in women, affecting roughly one in eight women in the...
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Hitting the (Moving) Target of Drug Resistant Cancers
Benita Katzenellenbogen has delved into the causes and treatments for breast cancer and other hormone-dependent cancers for virtually her entire career. Her tireless work in the field has established her as a world-renowned expert.