Breast Cancer

Mutations in noncoding genes could play big role in regulating cancer, study finds

2019-03-14

Professor Kannanganattu Prasanth led a team that found that certain genes that don’t code for proteins could play an important regulatory role in breast cancer.

Employing the Help of the BHPI Molecule to Boost Anti-Cancer Drug Treatments

2017-12-31

For decades, MCB and the University of Illinois have been at the forefront of understanding the role of estrogen and the estrogen receptor (ER) in causing breast cancer. This is essential work: Breast cancer is the most commonly diagnosed cancer in women, affecting roughly one in eight women in the...

Hitting the (Moving) Target of Drug Resistant Cancers

2017-12-31

Dr. Benita Katzenellenbogan, Swanlund Professor of Molecular and Integrative Physiology and Cell and Developmental Biology. Photo by L. Brian Stauffer

Benita Katzenellenbogen has delved into the causes and treatments for breast cancer and other hormone-dependent cancers for virtually her entire career. Her tireless work in the field has established her as a world-renowned expert.

Cholesterol byproduct hijacks immune cells, lets breast cancer spread

2017-10-12

The study, reported in Nature Communications, identifies new potential drug targets that could inhibit the creation or actions of the dangerous cholesterol byproduct.

Professor David Shapiro Named Eugene Howe Scholar in Biochemistry

2016-01-12

The Department of Biochemistry and the School of Molecular and Cellular Biology congratulate Professor David Shapiro, who has been named the Eugene Howe Scholar in Biochemistry.

Progress in Women's Reproductive Health and Fertility

2015-12-31

Tight shot of three pregnant women sit side by side, zoomed in on abdominal sections, faces cropped out.

Through the ages, fertility has played a central role in civilizations. Its cultural, socioeconomic, demographic, religious and global implications were and still are incalculable. A Wikipedia search for “fertility gods,” for example, yields a list of 35 cultures with one, and often...

Drs. Benita S. Katzenellenbogen and John A. Katzenellenbogen have been awarded the Fred Conrad Koch Lifetime Achievement Award by the Endocrine Society.

2015-09-01

The Society’s highest honor, this annual award recognizes lifetime achievements and exceptional contributions to the field of endocrinology. Dr. Benita Katzenellenbogen is currently the Swanlund Chaired Professor of Molecular and Integrative Physiology, and Dr. John Katzenellenbogen is the Swanlund...

Scientists discover a new role for estrogen in the pathology of breast cancer

2014-10-02

Biochemistry professor David Shapiro, M.D.-Ph.D student Neal Andruska, graduate student Xiaobin Zheng and their colleagues discovered a new mechanism by which estrogen contributes to the pathology of breast cancer. The findings are published in the journal Oncogene.

Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast cancer

2012-05-15

Assistant Professor of Biochemistry and Medical Biochemistry at the College of Medicine Lin-Feng Chen is corresponding author on a new study on RUNX3, a tumor suppressor in breast cancer.

Team identifies new breast cancer tumor suppressor and how it works

2011-06-30

In a new study, Assistant Professor of Biochemistry Lin-Feng Chen and colleagues identified a new breast cancer tumor suppressor protein, Runx3, and determined how it functioned.

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