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Xinzhu Yu

Profile picture for Xinzhu Yu

Contact Information

514 Burrill Hall
407 S Goodwin Ave
Urbana IL 61801

Research Areas

Assistant Professor of Molecular & Integrative Physiology

Research Description

Exploring Astrocyte Contributions to Neural Circuits, Behaviors and Diseases

Our emotions and thoughts are generated and processed by a network of different cell types in the brain, including both neurons and glial cells. As the most abundant glial cells, the "star cells" - astrocytes - were discovered more than a century ago but were only considered to have passive supporting functions to neurons. However, many recent studies have challenged this view and suggested that astrocytes are an integral part of the central nervous system.

There are two major questions that we are interested in:

  1. What are the cellular and molecular mechanisms by which astrocytes contribute to neural circuit plasticity, motor learning and memory, and the development of neuropsychiatric disorders?
  2. How can we link and predict circuit and behavioral alterations based on astrocyte signaling changes?

To tackle these questions, we will take a systematic approach with innovative genetic tools, in vivo imaging, electrophysiological recordings, next generation sequencing and computational modeling. We hope that our findings will expand the understanding of astrocyte physiology as well as offer mechanistic insights into new biomarkers for early diagnosis and potential therapeutic treatments for neuropsychiatric disorders.

Education

B.S., Tsinghua University, Beijing, China
M.S., Tsinghua University, Beijing, China
Ph.D., University of California Santa Cruz
Postdoc., University of California Santa Cruz
Postdoc., University of California Los Angeles

Awards and Honors

2019 NIH BRAIN Initiative Principal Investigators Meeting Travel Award, National Institutes of Health
2018 – 2019 Brain Research Institute Postdoctoral Award, University of California Los Angeles
2016 – 2017 American Heart Association Postdoctoral Fellowship, American Heart Association

Additional Campus Affiliations

Highlighted Publications

Yu X*, Nagai J*, Marti-Solano M, Soto JS, Coppola G, Babu MM and Khakh BS (2020) Context-specific striatal astrocyte molecular responses are phenotypically exploitable. Neuron. 2020 Oct 9:S0896-6273(20)30745-5. (* Equal contribution)

Yu X*, Nagai J* and Khakh BS (2020) Improved tools to study astrocytes. Nature Reviews Neuroscience. 2020 Mar;21(3):121-138. (* Equal contribution)

Yu X, Taylor AMW, Nagai J, Golshani P, Evans CJ, Coppola G and Khakh BS (2018) Reducing astrocyte calcium signaling in vivo alters striatal microcircuits and causes repetitive behavior. Neuron. 99(6):1170-1187

Hodges JL*, Yu X*, Gilmore A, Bennett H, Tjia M, Perna JF, Chen CC, Li X, Lu J and Zuo Y (2017) Astrocytic contributions to synaptic and learning abnormalities in a mouse model of Fragile X Syndrome. Biological Psychiatry. 82(2): 139-149. (* Equal contribution)

Yu X, Wang G, Gilmore A, Yee AX, Li X, Xu T, Smith SJ, Chen L and Zuo Y (2013) Accelerated experience-dependent pruning of cortical synapses in ephrin-A2 knockout mice. Neuron. 80(1):64-71.

Fu M, Yu X, Lu J and Zuo Y (2012) Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo. Nature. 483(7387):92-5.

Yu X, Zuo Y (2011) Spine plasticity in the motor cortex. Current Opinion in Neurobiology. 21(1):169-74.

Xu T*, Yu X*, Perlik A, Tobin W, Zweig J and Zuo Y (2009) Rapid formation and selective stabilization of synapses for enduring motor memories. Nature. 462(7275):915-9. (* Equal contribution)

Recent Publications

Yu, X. (2022). Hippocampal astrocytes represent navigation space. PLoS biology, 20(3), [e3001568]. https://doi.org/10.1371/journal.pbio.3001568

Yu, X., & Khakh, B. S. (2022). SnapShot: Astrocyte interactions. Cell, 185(1), 220-220.e1. https://doi.org/10.1016/j.cell.2021.09.029

Nagai, J., Yu, X., Papouin, T., Cheong, E., Freeman, M. R., Monk, K. R., Hastings, M. H., Haydon, P. G., Rowitch, D., Shaham, S., & Khakh, B. S. (2021). Behaviorally consequential astrocytic regulation of neural circuits. Neuron, 109(4), 576-596. https://doi.org/10.1016/j.neuron.2020.12.008

Nagai, J., Bellafard, A., Qu, Z., Yu, X., Ollivier, M., Gangwani, M. R., Diaz-Castro, B., Coppola, G., Schumacher, S. M., Golshani, P., Gradinaru, V., & Khakh, B. S. (2021). Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK. Neuron, 109(14), 2256-2274.e9. https://doi.org/10.1016/j.neuron.2021.05.023

Yu, X., Moye, S. L., & Khakh, B. S. (2021). Local and CNS-Wide astrocyte intracellular calcium signaling attenuation in vivo with CalExflox mice. Journal of Neuroscience, 41(21), 4556-4574. https://doi.org/10.1523/JNEUROSCI.0085-21.2021

View all publications on Illinois Experts

In the news

  • Professor Yu was one of ten new faculty hires made in the School of Molecular and Cellular Biology in the last three years. Yu is an assistant professor of molecular and integrative physiology and is an affiliate of the Beckman Institute.