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Drug Discovery

New faculty members begin teaching and research at U of I

The College of LAS is welcoming 38 new professors for the 2022-23 academic year. Their new positions range from clinical professors to assistant professors and an endowed position in more than 20 academic units, ranging from African American studies to economics, philosophy, statistics, and several...

Researchers determine Pol III “identity” as important regulatory mechanism and likely disease factor in cancer

Researchers at the University of Illinois Urbana-Champaign and Stanford University School of Medicine have identified a link between RNA polymerase III subunit composition and transcription, an advancement that has potential implications for future cancer research. Their findings were published in...

Mining microbial genomes to discover natural products

The world around us contains many chemicals that are useful for medicines, crop protection, and animal health. These chemicals—known as natural products—have typically been discovered by sheer luck. Unsurprisingly, traditional techniques often find the same products, like antibiotics, repeatedly...

Meet Kevin Van Bortle, assistant professor of cell and developmental biology

The School of Molecular & Cellular Biology and Department of Cell & Developmental Biology are thrilled to welcome new faculty member Kevin Van Bortle! He joins us from the Stanford University School of Medicine, where he conducted his postdoctoral research. We recently spoke with him about...

New approach eradicates breast cancer in mice

A new approach to treating breast cancer kills 95-100% of cancer cells in mouse models of human estrogen-receptor-positive breast cancers and their metastases in bone, brain, liver and lungs. The newly developed drug, called ErSO, quickly shrinks even large tumors to undetectable levels.

Researchers structurally characterize a dual-function transporter

The regulation of glutamate, an excitatory neurotransmitter abundant in the central nervous system, is critical for maintaining normal brain function. Glutamate regulation is achieved via extracellular transport of the amino acid. There are two primary classes of proteins involved in the transport...

Researchers examine the biological role of epigenetic regulator Brd4 in inflammasome activation

Inflammasomes play a critical role in the innate cellular immune response to pathogen infection. The inflammasome, a cytosolic multiprotein complex, recognizes substrates produced during infection or tissue damage, and triggers an inflammatory response by releasing the proinflammatory cytokine IL-...

New approach drives bacteria to produce potential antibiotic, antiparasitic compounds

Researchers have developed a method to spur the production of new antibiotic or antiparasitic compounds hiding in the genomes of actinobacteria, which are the source of drugs such as actinomycin and streptomycin and are known to harbor other untapped chemical riches. The scientists report their...

MCB researchers aim to speed up drug discovery through RiPPs

As the globe currently deals with the novel coronavirus pandemic, public interest in biological research has begun to grow. However, curative research takes time: drug discovery requires years of effort and financial resources to yield results. Even with focused endeavors, it would still take...