Biochemistry

Engineered immune cells recognize, attack human and mouse solid-tumor cancer cells

A method known as CAR-T therapy has been used successfully in patients with blood cancers such as lymphoma and leukemia. It modifies a patient’s own T-cells by adding a piece of an antibody that recognizes unique features on the surface of cancer cells. In a new study, researchers report that they...

New approach drives bacteria to produce potential antibiotic, antiparasitic compounds

Researchers have developed a method to spur the production of new antibiotic or antiparasitic compounds hiding in the genomes of actinobacteria, which are the source of drugs such as actinomycin and streptomycin and are known to harbor other untapped chemical riches. The scientists report their...

Finding a new link between cellular respiration and virulence in S. aureus

Due in part to COVID-19, more and more people realize the importance of taking early steps to understand the virulence mechanisms of pathogens, especially in the face of their widespread resistance to drugs. Doing so gives researchers and clinicians a head start in preparing against future...

Team deciphers how myotonic dystrophy generates lethal heart dysfunctions

Roughly 80% of people with myotonic dystrophy – a common form of muscular dystrophy – experience dangerous heart ailments, and heart rhythm defects are the second-leading cause of death in those with the condition. In a new study, researchers traced the molecular events that lead to heart...

MCB's Commitment to Diversity and Equity

The School of Molecular and Cellular Biology would like to follow up on the statement sent out by the University of Illinois on Saturday. As noted by UI President Timothy Killeen, “The horrifying image of George Floyd dying as a police officer knelt on his neck is one that will be forever burned...

MCB researchers aim to speed up drug discovery through RiPPs

As the globe currently deals with the novel coronavirus pandemic, public interest in biological research has begun to grow. However, curative research takes time: drug discovery requires years of effort and financial resources to yield results. Even with focused endeavors, it would still take...

MCB faculty join Congressman for discussion about COVID-19 testing, vaccines, treatments

Faculty in the School of Molecular and Cellular Biology shared the latest news and insights on COVID-19 testing, vaccines, and antibody research with U.S. Congressman Bill Foster this weekend as part of the representative’s Science Saturdays discussion on Facebook Live.

Researchers find mutation hotspots for severe form of genetic epilepsy that give insights into the underlying pathogenesis

The lab of Hee Jung Chung, Associate Professor in the Department of Molecular and Integrative Physiology, recently released a paper in Scientific Reports titled “Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy” to help fill in the gaps in our...

A novel approach to a new career

Alumna Carole Stivers worked as a biochemist in Silicon Valley—and then started anew as a science fiction writer.

Prof. Stephen Sligar receives the Christian B. Anfinsen Award

The Christian B. Anfinsen Award, sponsored by The Protein Society, recognizes technological achievement or significant methodological advances in the field of protein science. The recipient of this award in 2020 is Professor Stephen Sligar, professor of Biochemistry and former director of the...