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Epilepsy

New study suggests link between temporal lobe epilepsy and reproductive endocrine dysfunction

A new study from the University of Illinois further helps explain links between epilepsy and reproductive comorbidities. The Christian-Hinman laboratory's findings were published in the journal Neurobiology of Disease.

Recent research from Christian-Hinman lab provides foundation for new experimental designs to study epilepsy

Patients with temporal lobe epilepsy, the most common form of focal epilepsy, often have seizures that start from one side of the hippocampus and not the other. Such patients may also experience complications such as cognitive impairment and reproductive endocrine disruption. Although it’s been...

MCB team identifies compound with potent antiseizure effects

Researchers studying epileptic seizures of the temporal lobe – the most common type of epilepsy – discovered a compound that reduces seizures in the hippocampus, a brain region where many such seizures originate. The compound, known as TC-2153, lessened the severity of seizures in mice. The...

Professor Catherine Christian-Hinman: Connecting estrogen to epilepsy

Meet MCB: Dr. Christian-Hinman’s lab focuses on understanding the neural mechanisms linking epilepsy and comorbid reproductive endocrine disorder.

Gene mutation leads to epileptic encephalopathy symptoms, neuron death in mice

Mice with a genetic mutation that’s been observed in patients with epileptic encephalopathy, a severe form of congenital epilepsy, exhibit not only the seizure, developmental and behavioral symptoms of the disorder, but also neural degeneration and inflammation in the brain, University of Illinois...

Detailed map of ion-channel structure could steer development of new therapeutic strategies for epilepsy

Researchers at the University of Illinois Urbana-Champaign are hopeful their findings on the gating mechanisms behind epilepsy-associated potassium channels could provide a foundation for new therapeutic strategies for treating epilepsy, especially in young patients. Their research was recently...

Mouse model of epilepsy may yield insights into relationship between seizures and reproductive cycle in women

Recent research from Professor Catherine Christian-Hinman in the Department of Molecular and Integrative Physiology has identified an animal model capable of modeling some aspects of catamenial epilepsy without hormone treatments, creating exciting possibilities in the field for advancement in...

Using magnetic resonance elastography to detect epilepsy

A new study uses magnetic resonance elastography to compare the stiffness of the hippocampus in patients who have epilepsy with healthy individuals. The technique can improve the detection and characterization of the disease.

Researchers find mutation hotspots for severe form of genetic epilepsy that give insights into the underlying pathogenesis

The lab of Hee Jung Chung, Associate Professor in the Department of Molecular and Integrative Physiology, recently released a paper in Scientific Reports titled “Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy” to help fill in the gaps in our...

Study reveals neuronal response following chronic activation of an epilepsy- and autism-linked receptor

Group 1 metabotropic glutamate receptors (Gp1 mGluRs) are essential for neuroplasticity, neurodevelopment and cognition, but chronically active Gp1 mGluRs has been linked to many pathologic conditions including epilepsy and autism spectrum disorders. To characterize the effects of chronically...